FURIN

furin (paired basic amino acid cleaving enzyme)

FURIN is a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. It encodes a type 1 membrane bound protease that is expressed in many tissues, including neuroendocrine, liver, gut, and brain. The encoded protein undergoes an initial autocatalytic processing event in the ER and then sorts to the trans-Golgi network through endosomes where a second autocatalytic event takes place and the catalytic activity is acquired. The product of this gene is one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. Some of its substrates include proparathyroid hormone, transforming growth factor beta 1 precursor, proalbumin, pro-beta-secretase, membrane type-1 matrix metalloproteinase, beta subunit of pro-nerve growth factor and von Willebrand factor. It is also thought to be one of the proteases responsible for the activation of HIV envelope glycoproteins gp160 and gp140 and may play a role in tumor progression. This gene is located in close proximity to family member proprotein convertase subtilisin/kexin type 6 and upstream of the FES oncogene. Alternative splicing results in multiple transcript variants.

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Products

Antibodies (65)

Type

Primary (65)

Target

FURIN (65)

Reactivity

Human (49)

Mouse (28)

Rat (7)

Bovine (2)

Chimpanzee (3)

Dog (4)

Gibbon (3)

Guinea pig (3)

Hamster (3)

Horse (4)

Monkey (1)

Pig (8)

Rabbit (3)

Sheep (1)

Zebrafish (3)

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Application

IHC (8)

IHC-P (4)

WB (58)

ELISA (8)

ICC (4)

IP (3)

Peptide-ELISA (2)

Host

rabbit (62)

mouse (2)

goat (1)

Product Group

Antibodies to Coronavirus-Associated Targets (65)

IHCPlus (3)

Isotype

IgG (12)

IgG1 (1)

IgG2a (1)

Clonality

monoclonal mc (2)

polyclonal pc (63)

Clone

MON-148 (1)

Format

APC (5)

APC Conjugated (5)

Biotin Conjugated (8)

Cy3 Conjugated (5)

Cy7 Conjugated (5)

FITC Conjugated (8)

HRP Conjugated (7)

PE Conjugated (5)

Unconjugated (22)

Epitope

aa587-748 (10)

aa105-221 (8)

aa385-500 (8)

aa418-573 (8)

aa578-734 (8)

aa107-156 (4)

Internal Region (1)

aa187-198 (1)

aa591-794 (1)

aa731-794 (1)

aa740-790 (1)

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Publications

No (65)

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FURIN Antibody (clone MON-148) LS-C23722

Antibody:

FURIN Mouse anti-Human Monoclonal (MON-148) Antibody

Reactivity:

Mouse, Human

Applications:

ICC, IP, WB

Format:

Unconjugated

Price:

100 µl/$740

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FURIN Antibody (aa187-198) LS-C23719

Antibody:

FURIN Rabbit anti-Human Polyclonal (aa187-198) Antibody

Reactivity:

Human

Applications:

ELISA, IP, WB

Format:

Unconjugated

Price:

1 Each/$725

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FURIN Antibody LS-C23718

Antibody:

FURIN Mouse anti-Human Monoclonal Antibody

Reactivity:

Human

Applications:

ICC, IP, WB

Format:

Unconjugated

Price:

100 µl/$866

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FURIN Antibody LS-C349148

Antibody:

FURIN Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

20 µl/$275; 100 µl/$389

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FURIN Antibody (aa385-500) LS-B14617

Antibody:

FURIN Rabbit anti-Human Polyclonal (aa385-500) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$460

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FURIN Antibody (aa587-748) LS-B15004

Antibody:

FURIN Rabbit anti-Human Polyclonal (aa587-748) Antibody

Reactivity:

Pig, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$460

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FURIN Antibody (aa105-221) LS-B15003

Antibody:

FURIN Rabbit anti-Human Polyclonal (aa105-221) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$460

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FURIN Antibody (aa587-748, PE) LS-C725626

Antibody:

FURIN Rabbit anti-Human Polyclonal (aa587-748) (PE) Antibody

Reactivity:

Pig, Human

Applications:

WB

Format:

PE Conjugated

Price:

100 µl/$407; 200 µl/$491; 500 µl/$850; 1 ml/$1,008; 2 ml/$1,308; 5 ml/$2,451

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FURIN Antibody LS-C660264

Antibody:

FURIN Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

100 µg/$331

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FURIN Antibody LS-C766689

Antibody:

FURIN Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

60 µl/$331; 120 µl/$403; 200 µl/$529

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FURIN Antibody LS-C498899

Antibody:

FURIN Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

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FURIN Antibody LS-C781111

Antibody:

FURIN Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$357

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FURIN Antibody (aa587-748, Biotin) LS-C422232

Antibody:

FURIN Rabbit anti-Human Polyclonal (aa587-748) (Biotin) Antibody

Reactivity:

Human

Applications:

ICC, WB

Format:

Biotin Conjugated

Price:

100 µl/$318

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FURIN Antibody (aa587-748, FITC) LS-C422234

Antibody:

FURIN Rabbit anti-Human Polyclonal (aa587-748) (FITC) Antibody

Reactivity:

Human

Applications:

ICC, WB

Format:

FITC Conjugated

Price:

100 µl/$328

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FURIN Antibody LS-C809033

Antibody:

FURIN Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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FURIN Antibody (aa740-790) LS-C148556

Antibody:

FURIN Rabbit anti-Human Polyclonal (aa740-790) Antibody

Reactivity:

Mouse, Dog, Bovine, Rat, Horse, Human, Monkey

Applications:

IHC

Format:

Unconjugated

Price:

100 µg/$386

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FURIN Antibody (aa418-573) LS-C294173

Antibody:

FURIN Rabbit anti-Mouse Polyclonal (aa418-573) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$311; 200 µl/$355; 500 µl/$499; 1 ml/$571; 2 ml/$777; 5 ml/$1,261

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FURIN Antibody (aa578-734) LS-C294177

Antibody:

FURIN Rabbit anti-Mouse Polyclonal (aa578-734) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$311; 200 µl/$355; 500 µl/$499; 1 ml/$571; 2 ml/$777; 5 ml/$1,261

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FURIN Antibody (aa578-734, Biotin) LS-C422233

Antibody:

FURIN Rabbit anti-Mouse Polyclonal (aa578-734) (Biotin) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$321; 200 µl/$369; 500 µl/$527; 1 ml/$611; 2 ml/$842; 5 ml/$1,387

• Unconjugated
• Biotin

• Unconjugated
• Biotin

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FURIN Antibody (Internal Region) LS-C742496

Antibody:

FURIN Goat anti-Human Polyclonal (Internal Region) Antibody

Reactivity:

Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µg/$503

Select

FURIN Antibody (aa731-794) LS-C311682

Antibody:

FURIN Rabbit anti-Human Polyclonal (aa731-794) Antibody

Reactivity:

Mouse, Sheep, Bovine, Rat, Human

Applications:

ELISA

Format:

Unconjugated

Price:

100 µl/$450

Select

FURIN Antibody (aa107-156) LS-C111020

Antibody:

FURIN Rabbit anti-Human Polyclonal (aa107-156) Antibody

Reactivity:

Mouse, Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

Select

FURIN Antibody LS-C783472

Antibody:

FURIN Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

25 µg/$281; 100 µg/$400

Select

FURIN Antibody LS-C748390

Antibody:

FURIN Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

WB

Format:

Unconjugated

Price:

20 µl/$275; 100 µl/$389

Select

FURIN Antibody (aa591-794) LS-C344036

Antibody:

FURIN Rabbit anti-Human Polyclonal (aa591-794) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

10 µg/$318; 100 µg/$470

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