FURIN

furin (paired basic amino acid cleaving enzyme)

FURIN is a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. It encodes a type 1 membrane bound protease that is expressed in many tissues, including neuroendocrine, liver, gut, and brain. The encoded protein undergoes an initial autocatalytic processing event in the ER and then sorts to the trans-Golgi network through endosomes where a second autocatalytic event takes place and the catalytic activity is acquired. The product of this gene is one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. Some of its substrates include proparathyroid hormone, transforming growth factor beta 1 precursor, proalbumin, pro-beta-secretase, membrane type-1 matrix metalloproteinase, beta subunit of pro-nerve growth factor and von Willebrand factor. It is also thought to be one of the proteases responsible for the activation of HIV envelope glycoproteins gp160 and gp140 and may play a role in tumor progression. This gene is located in close proximity to family member proprotein convertase subtilisin/kexin type 6 and upstream of the FES oncogene. Alternative splicing results in multiple transcript variants.

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Antibodies (66)

Proteins (13)

ELISA Kits (12)

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Custom (2)

Over-Expression Cell Culture Supernatant (1)

Over-Expression Lysate (3)

Primary (66)

Recombinant (9)

Sandwich (10)

Target

FURIN (91)

Reactivity

Human (56)

Mouse (30)

Rat (9)

Bovine (3)

Chimpanzee (3)

Dog (4)

Gibbon (3)

Guinea pig (3)

Hamster (3)

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Monkey (1)

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Rabbit (3)

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IHC (8)

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WB (58)

ELISA (8)

ICC (4)

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Peptide-ELISA (2)

Host

rabbit (63)

mouse (2)

goat (1)

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Antibodies to Coronavirus-Associated Targets (65)

Coronavirus Detection (12)

ELISA Kits for Associated Targets (12)

IHCPlus (4)

SARS-CoV-2 Associated Proteins (13)

Isotype

IgG (12)

IgG1 (1)

IgG2a (1)

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monoclonal mc (2)

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Clone

MON-148 (1)

Format

96-Well Microplate (3)

96-Well Strip Plate (9)

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Epitope

aa587-748 (10)

aa105-221 (8)

aa385-500 (8)

aa418-573 (8)

aa578-734 (8)

aa107-156 (4)

Internal Region (1)

aa187-198 (1)

aa591-794 (1)

aa731-794 (1)

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Publications

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Sample Type

Cell Culture Supernatants (3)

Cell Lysates (3)

Plasma (6)

Serum (6)

Tissue Homogenates (6)

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His (4)

His, C-Terminal (1)

His, N-Terminal (2)

His-GST (2)

Myc-DDK (Flag) (3)

Species

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Mouse (2)

Source

293T Cells (1)

E. coli (6)

HEK 293 Cells (4)

High Five Cells (1)

Wheat Germ Extract (1)

Purification

Purified (3)

Supernatant (1)

Low Endotoxin Level

Low endotoxin level (1)

Biologically Active

Biologically active (1)

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Mouse FURIN (Sandwich ELISA) ELISA Kit - LS-F32096

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

46.875 - 3000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

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FURIN Antibody (clone MON-148) LS-C23722

Antibody:

FURIN Mouse anti-Human Monoclonal (MON-148) Antibody

Reactivity:

Mouse, Human

Applications:

ICC, IP, WB

Format:

Unconjugated

Price:

100 µl/$740

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FURIN Antibody (aa187-198) LS-C23719

Antibody:

FURIN Rabbit anti-Human Polyclonal (aa187-198) Antibody

Reactivity:

Human

Applications:

ELISA, IP, WB

Format:

Unconjugated

Price:

1 Each/$725

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FURIN Antibody LS-C23718

Antibody:

FURIN Mouse anti-Human Monoclonal Antibody

Reactivity:

Human

Applications:

ICC, IP, WB

Format:

Unconjugated

Price:

100 µl/$866

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Rat FURIN (Sandwich ELISA) ELISA Kit - LS-F9935

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$783

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FURIN Antibody LS-C349148

Antibody:

FURIN Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

20 µl/$275; 100 µl/$389

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FURIN Antibody (aa385-500) LS-B14617

Antibody:

FURIN Rabbit anti-Human Polyclonal (aa385-500) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$460

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FURIN Antibody (aa587-748, PE) LS-C725626

Antibody:

FURIN Rabbit anti-Human Polyclonal (aa587-748) (PE) Antibody

Reactivity:

Pig, Human

Applications:

WB

Format:

PE Conjugated

Price:

100 µl/$407; 200 µl/$491; 500 µl/$850; 1 ml/$1,008; 2 ml/$1,308; 5 ml/$2,451

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FURIN Antibody (aa587-748) LS-B15004

Antibody:

FURIN Rabbit anti-Human Polyclonal (aa587-748) Antibody

Reactivity:

Pig, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$460

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FURIN Antibody (aa105-221) LS-B15003

Antibody:

FURIN Rabbit anti-Human Polyclonal (aa105-221) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$460

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Human FURIN Protein (Recombinant His) - LS-G3242

Source:

E. coli

Tag:

His

Price:

100 µg/$361; 500 µg/$739; 20 µg/$261

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Human FURIN Protein (Recombinant His, C-Terminal) - LS-G476

Source:

High Five Cells

Tag:

His, C-Terminal

Biological Activity:

Biologically active

Endotoxin Level:

Less than 0.1 ng/µg of protein (less than 1EU/µg).

Molecular Weight:

61.7 kDa

Price:

2 µg/$268; 10 µg/$349

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Human FURIN Protein (Recombinant GST) (Full Length) - LS-G29609

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

110.22 kDa

Price:

10 µg/$479; 25 µg/$670

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IHC-plus™ FURIN Antibody LS-A13629

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Antibody:

FURIN Rabbit anti-Human Polyclonal Antibody

Applications:

IHC-P

Format:

Unconjugated

Price:

50 µg/$460

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FURIN Antibody LS-C660264

Antibody:

FURIN Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

100 µg/$331

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FURIN Antibody LS-C766689

Antibody:

FURIN Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

60 µl/$331; 120 µl/$403; 200 µl/$529

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FURIN Antibody LS-C498899

Antibody:

FURIN Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

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FURIN Antibody LS-C781111

Antibody:

FURIN Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$357

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FURIN Antibody (aa587-748, Biotin) LS-C422232

Antibody:

FURIN Rabbit anti-Human Polyclonal (aa587-748) (Biotin) Antibody

Reactivity:

Human

Applications:

ICC, WB

Format:

Biotin Conjugated

Price:

100 µl/$318

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FURIN Antibody (aa587-748, FITC) LS-C422234

Antibody:

FURIN Rabbit anti-Human Polyclonal (aa587-748) (FITC) Antibody

Reactivity:

Human

Applications:

ICC, WB

Format:

FITC Conjugated

Price:

100 µl/$328

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FURIN Antibody LS-C809033

Antibody:

FURIN Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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FURIN Antibody (aa740-790) LS-C148556

Antibody:

FURIN Rabbit anti-Human Polyclonal (aa740-790) Antibody

Reactivity:

Mouse, Dog, Bovine, Rat, Horse, Human, Monkey

Applications:

IHC

Format:

Unconjugated

Price:

100 µg/$386

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FURIN Antibody (aa418-573) LS-C294173

Antibody:

FURIN Rabbit anti-Mouse Polyclonal (aa418-573) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$311; 200 µl/$355; 500 µl/$499; 1 ml/$571; 2 ml/$777; 5 ml/$1,261

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FURIN Antibody (aa578-734) LS-C294177

Antibody:

FURIN Rabbit anti-Mouse Polyclonal (aa578-734) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$311; 200 µl/$355; 500 µl/$499; 1 ml/$571; 2 ml/$777; 5 ml/$1,261

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FURIN Antibody (Internal Region) LS-C742496

Antibody:

FURIN Goat anti-Human Polyclonal (Internal Region) Antibody

Reactivity:

Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µg/$503

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