FTO

fat mass and obesity associated

Dioxygenase that repairs alkylated DNA and RNA by oxidative demethylation. Has highest activity towards single-stranded RNA containing 3-methyluracil, followed by single-stranded DNA containing 3-methylthymine. Has low demethylase activity towards single-stranded DNA containing 1-methyladenine or 3-methylcytosine. Specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. Has no activity towards 1-methylguanine. Has no detectable activity towards double-stranded DNA. Requires molecular oxygen, alpha-ketoglutarate and iron. Contributes to the regulation of the global metabolic rate, energy expenditure and energy homeostasis. Contributes to the regulation of body size and body fat accumulation.

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Products

Proteins (5)

Type

Over-Expression Lysate (2)

Recombinant (3)

Target

FTO (5)

Publications

No (5)

Tag

GST (1)

His, N-Terminal (1)

Myc-DDK (Flag) (3)

Species

Human (4)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Purification

Purified (2)

Low Endotoxin Level

Low endotoxin level (1)

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Human FTO Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G72660

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

58.1 kDa

Price:

20 µg/$1,107

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Human FTO Protein (Recombinant His, N-Terminal) (aa2-505) - LS-G3806

Source:

E. coli

Tag:

His, N-Terminal

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

~65kDa (SDS-PAGE)

Price:

50 µg/$598; 10 µg/$365

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Human FTO Protein (Recombinant GST) (Full Length) - LS-G35143

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

41.8 kDa

Price:

10 µg/$479; 25 µg/$670

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Human FTO Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G93203

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

58.1 kDa

Price:

20 µg/$215

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FTO Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G120218

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

58.1 kDa

Price:

100 µg/$710

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