FOXO1 / FKHR

forkhead box O1

Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress. Binds to the insulin response element (IRE) with consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'-TT[G/A]TTTAC-3'. Activity suppressed by insulin. Main regulator of redox balance and osteoblast numbers and controls bone mass. Orchestrates the endocrine function of the skeleton in regulating glucose metabolism. Acts syngernistically with ATF4 to suppress osteocalcin/BGLAP activity, increasing glucose levels and triggering glucose intolerance and insulin insensitivity. Also suppresses the transcriptional activity of RUNX2, an upstream activator of osteocalcin/BGLAP. In hepatocytes, promotes gluconeogenesis by acting together with PPARGC1A to activate the expression of genes such as IGFBP1, G6PC and PPCK1. Important regulator of cell death acting downstream of CDK1, PKB/AKT1 and SKT4/MST1. Promotes neural cell death. Mediates insulin action on adipose. Regulates the expression of adipogenic genes such as PPARG during preadipocyte differentiation and, adipocyte size and adipose tissue-specific gene expression in response to excessive calorie intake. Regulates the transcriptional activity of GADD45A and repair of nitric oxide-damaged DNA in beta-cells. Required for the autophagic cell death induction in response to starvation or oxidative stress in a transcription-independent manner.

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Products

Proteins (7)

Type

Over-Expression Lysate (2)

Recombinant (5)

Target

FOXO1 / FKHR (7)

Publications

No (7)

Tag

GST, N-terminus (2)

His-T7 (1)

Myc-DDK (Flag) (3)

Species

Human (5)

Mouse (1)

Source

293T Cells (1)

E. coli (2)

HEK 293 Cells (2)

Wheat Germ Extract (2)

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Human FOXO1 / FKHR Protein (Recombinant) (aa333-557) - LS-G12768

Source:

E. coli

Tag:

None

Molecular Weight:

27.7 kDa

Price:

10 µg/$291; 50 µg/$502; 100 µg/$802; 200 µg/$1,002; 1 mg/$2,144; 500 µg/$1,668; 5 mg/$3,501; 2 mg/$2,334

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Mouse FOXO1 / FKHR Protein (Recombinant His-T7) (aa222-469) - LS-G12774

Source:

E. coli

Tag:

His-T7

Molecular Weight:

30.4 kDa

Price:

10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204

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Human FOXO1 / FKHR Protein (Recombinant GST, N-terminus) (aa452-555) - LS-G58585

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human FOXO1 / FKHR Protein (Recombinant GST, N-terminus) (aa556-655) - LS-G58586

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human FOXO1 / FKHR Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G75969

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

69.5 kDa

Price:

20 µg/$150

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Human FOXO1 / FKHR Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G65652

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

69.5 kDa

Price:

20 µg/$1,107

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FOXO1 / FKHR Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G118242

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

69.5 kDa

Price:

100 µg/$494

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