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Binds to the consensus sequence 5'-A[AT]T[AG]TTTGTTT-3' and acts as a transcriptional repressor. Also acts as a transcriptional activator. Promotes development of neural crest cells from neural tube progenitors. Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. Required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis.
Gene Name: | forkhead box D3 |
Family/Subfamily: | Transcription factor , not assigned-Transcription factor |
Synonyms: | FOXD3, AIS1, Drosophila forkhead homologue, Genesis, Forkhead box protein D3, Forkhead box D3, HFH2, VAMAS2 |
Target Sequences: | NM_012183 NP_036315.1 Q9UJU5 |
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