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The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Gene Name: | FBJ murine osteosarcoma viral oncogene homolog B |
Synonyms: | FOSB, Activator protein 1, AP-1, GOS3, G0s3, GOSB, Protein fosB |
Target Sequences: | NM_006732 NP_006723.2 P53539 |
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