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FOLR1 / Folate Receptor Alpha
folate receptor 1 (adult)
Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. Required for normal embryonic development and normal cell proliferation.
| Gene Name: | folate receptor 1 (adult) |
| Synonyms: | FOLR1, Adult folate-binding protein, FBP, Folate receptor alpha, KB cells FBP, Folate binding protein, Folate receptor 1, Folate receptor 1 (adult), Folate receptor, adult, FOLR, FR-alpha |
| Target Sequences: | NM_016730 NP_057942.1 P15328 |
Publications (6)
1
A folate receptor-targeted lipoplex delivering interleukin-15 gene for colon cancer immunotherapy. Liang X, Luo M, Wei XW, Ma CC, Yang YH, Shao B, Liu YT, Liu T, Ren J, Liu L, He ZY, Wei YQ. Oncotarget. 2016 7:52207-52217. (Flo; Mouse)
[Full Text Article]
[PubMed:27438147]
[PMC:PMC5239545]
Related Antibodies: LS-B5727.
2
Expression status of folate receptor alpha is a predictor of survival in pancreatic ductal adenocarcinoma. Cai L, Michelakos T, Ferrone CR, Zhang L, Deshpande V, Shen Q, DeLeo A, Yamada T, Zhang G, Ferrone S, Wang X. Oncotarget. 2017 8:37646-37656. (IHC, Flo; Human)
[Full Text Article]
[PubMed:28430580]
[PMC:PMC5514937]
Related Antibodies: LS-B5727, LS-C129132.
3
Intraoperative near-infrared fluorescence imaging targeting folate receptors identifies lung cancer in a large-animal model. Keating JJ, Runge JJ, Singhal S, Nims S, Venegas O, Durham AC, Swain G, Nie S, Low PS, Holt DE. Cancer. 2017 May;123:1051-1060. [Full Text Article]
[PubMed:28263385]
[PMC:PMC5341137]
Related Antibodies: LS-B5727.
☰ Filters
Products
ELISA Kits
(15)
Type
Custom
(4)
Sandwich
(10)
Sandwich CLIA
(1)
Target
FOLR1 / Folate Receptor Alpha
(15)
Reactivity
Human
(9)
Mouse
(5)
Format
12 x 8-Well Microstrips
(1)
96-Well Microplate
(3)
96-Well Strip Plate
(11)
Publications
No
(15)
Sample Type
Breast Milk
(1)
Cell Culture Supernatants
(4)
Cell Lysates
(1)
Plasma
(11)
Saliva
(1)
Serum
(11)
Tissue Homogenates
(5)
Urine
(2)
Sandwich
96-Well Microplate
Human
46.9 - 3000 pg/ml
Colorimetric - 450nm (TMB)
Breast Milk, Cell Culture Supernatants, Plasma, Saliva, Serum, Urine
1 Plate/$699
Sandwich
12 x 8-Well Microstrips
Human
94 - 6000 pg/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Plasma, Serum
1 Plate/$534
Sandwich CLIA
96-Well Strip Plate
Human
1.37 - 1000 pg/ml
Chemiluminescent
Plasma, Serum, Tissue Homogenates
1 Plate/$851
Custom
96-Well Microplate
Human
Colorimetric - 450nm (TMB)
1 Plate/$559
Sandwich
96-Well Microplate
Mouse
46.9 - 3000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$699
Sandwich
96-Well Strip Plate
Mouse
7.81 - 500 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$748
Sandwich
96-Well Strip Plate
Human
15.63 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$792
Sandwich
96-Well Strip Plate
Human
125 - 8000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$897
Custom
96-Well Strip Plate
Mouse
Colorimetric - 450nm (TMB)
1 Plate/$669
Custom
96-Well Strip Plate
Colorimetric - 450nm (TMB)
1 Plate/$669
Custom
96-Well Strip Plate
Human
Colorimetric - 450nm (TMB)
1 Plate/$585
Sandwich
96-Well Strip Plate
Mouse
46.9 - 3000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$624
Sandwich
96-Well Strip Plate
Mouse
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
Sandwich
96-Well Strip Plate
Human
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
Sandwich
96-Well Strip Plate
Human
46.9 - 3000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Urine
1 Plate/$624
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