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FOLH1 / PSMA
folate hydrolase (prostate-specific membrane antigen) 1
FOLH1 / PSMA is a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. A mutation in this gene may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. Expression of this protein in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region. Alternative splicing gives rise to multiple transcript variants encoding several different isoforms.
| Gene Name: | folate hydrolase (prostate-specific membrane antigen) 1 |
| Synonyms: | FOLH1, Folate hydrolase 1, GCPII, Glutamate carboxypeptidase II, Folate hydrolase, GCP2, NAALAD1, NAALAdase, NAALADase I, PSM, FGCP, FOLH, Glutamate carboxylase II, Glutamate carboxypeptidase 2, MGCP, PSMA |
| Target Sequences: | NM_004476 NP_004467.1 Q04609 |
Publications (2)
1
In vitro-transcribed antigen receptor mRNA nanocarriers for transient expression in circulating T cells in vivo. N N Parayath, S B Stephan, A L Koehne, P S Nelson, M T Stephan. Nature communications. 2020 November;11:6080. [Full Text Article]
[PubMed:33247092]
[PMC:PMC7695830]
Related Antibodies: LS-C317473.
2
Comparative analysis of monoclonal antibodies against prostate-specific membrane antigen (PSMA). Tykvart J, Navr[Character e1]til V, Sedl[Character e1]k F, Corey E, Colombatti M, Fracasso G, Koukol[Character ed]k F, Ba[Character 159]inka C, S[Character e1]cha P, Konvalinka J. The Prostate. Dec;74:1674-90. [Full Text Article]
[PubMed:25262926]
Related Antibodies: LS-B3040.
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FOLH1 / PSMA
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(123)
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Cancer Pathology
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FOLH1 / PSMA Mouse anti-Human Monoclonal (Y-PSMA1) Antibody
Human
ELISA, IHC-Fr, IHC-P, WB
Unconjugated
50 µg/$460
FOLH1 / PSMA Mouse anti-Human Monoclonal (3H5) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
50 µl/$460
Cancer Pathology
Cancer
FOLH1 / PSMA Mouse anti-Human Monoclonal (5C4) Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated
50 µl/$460
FOLH1 / PSMA Mouse anti-Human Monoclonal (aa44-750) (GCP-04) Antibody
Rat, Pig, Human
IHC, IHC-P, WB
Unconjugated
50 µg/$535
FOLH1 / PSMA Mouse anti-Human Monoclonal (C-Terminus) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$595
FOLH1 / PSMA Mouse anti-Human Monoclonal (107.1A4) Antibody
Human
ELISA, Flo, ICC, IHC, IHC-Fr, IHC-P
Unconjugated
0.1 mg/$424
FOLH1 / PSMA Rabbit anti-Human Polyclonal (aa161-190) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
400 µl/$393
FOLH1 / PSMA Rabbit anti-Mouse Polyclonal Antibody
Mouse
WB
Unconjugated
100 µl/$311; 200 µl/$355; 1 ml/$571; 2 ml/$777; 5 ml/$1,261
FOLH1 / PSMA Rabbit anti-Mouse Polyclonal (FITC) Antibody
Mouse
WB
FITC Conjugated
100 µl/$352; 200 µl/$412; 1 ml/$777; 2 ml/$1,014; 5 ml/$1,765
FOLH1 / PSMA Rabbit anti-Human Polyclonal (aa274-587) (Biotin) Antibody
Rat, Human
WB
Biotin Conjugated
100 µl/$319; 200 µl/$365; 500 µl/$519; 1 ml/$596; 2 ml/$824; 5 ml/$1,348
Cancer Pathology
Cancer
FOLH1 / PSMA Mouse anti-Human Monoclonal (5A9) Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated
50 µl/$460
Cancer Pathology
Cancer
FOLH1 / PSMA Mouse anti-Human Monoclonal (Y-PSMA2 ) Antibody
Human
ELISA, IF, IHC, IHC-Fr, IHC-P, WB
Unconjugated
50 µg/$460
FOLH1 / PSMA Mouse anti-Human Monoclonal (GCP-05) Antibody
Human
Flo, ICC, IP
Unconjugated
0.1 mg/$344
FOLH1 / PSMA Mouse anti-Human Monoclonal (PE) (GCP-05) Antibody
Human
Flo, ICC, IP
PE Conjugated
0.1 mg/$442
Sandwich
96-Well Microplate
Human
4.69 - 300 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$771
E. coli
6His, N-terminus
83.2 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
FOLH1 / PSMA Mouse anti-Human Monoclonal (aa117-351) (K1H7) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$460
FOLH1 / PSMA Mouse anti-Human Monoclonal (2D10E10) Antibody
Human
ELISA, Flo, WB
Unconjugated
100 µl/$459
FOLH1 / PSMA Rabbit anti-Human Polyclonal (HRP) Antibody
Human
ELISA, IHC, IHC-P, WB
HRP Conjugated
50 µg/$294; 100 µg/$360
FOLH1 / PSMA Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA, IHC, IHC-P, WB
Biotin Conjugated
50 µg/$294; 100 µg/$360
FOLH1 / PSMA Rabbit anti-Human Polyclonal (FITC) Antibody
Human
ELISA, IHC, IHC-P, WB
FITC Conjugated
50 µg/$294; 100 µg/$360
FOLH1 / PSMA Mouse anti-Human Monoclonal (Azide-free, BSA-free) (FOLH1/2363) Antibody
Human
IHC-P, WB
Unconjugated, Azide-free, BSA-free
100 µg/$574
FOLH1 / PSMA Mouse anti-Human Monoclonal (FITC) (107-1A4) Antibody
Human
Flo
FITC Conjugated
50 µg/$452
FOLH1 / PSMA Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
WB
Unconjugated
100 µl/$424
FOLH1 / PSMA Mouse anti-Human Monoclonal (GCP-04) Antibody
Mouse, Porcine, Rat, Human
ICC, IHC-P, WB
Unconjugated
0.1 mg/$344
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