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FNDC5 / Irisin

fibronectin type III domain containing 5

FNDC5 / Irisin is a secreted protein that is released from muscle cells during exercise. The encoded protein may participate in the development of brown fat. Translation of the precursor protein initiates at a non-AUG start codon at a position that is conserved as an AUG start codon in other organisms. Alternative splicing results in multiple transcript variants.

Gene Name: fibronectin type III domain containing 5
Synonyms: FNDC5, Irisin, FRCP2
Target Sequences: Q8NAU1 Q8NAU1

Publications (3)

1
Hypergravity as a gravitational therapy mitigates the effects of knee osteoarthritis on the musculoskeletal system in a murine model. Benoit Dechaumet, Damien Cleret, Marie-Thérèse Linossier, Arnaud Vanden-Bossche, Stéphanie Chanon, Etienne Lefai, Norbert Laroche, Marie-Hélène Lafage-Proust, Laurence Vico. PloS one. 2020 December;15:e0243098. [Full Text Article] [PubMed:33296408] [PMC:PMC7725345]
2
Effects of dapagliflozin on the serum levels of fibroblast growth factor 21 and myokines and muscle mass in Japanese patients with type 2 diabetes: A randomized, controlled trial. Hajime Yamakage, Masashi Tanaka, Takayuki Inoue, Shinji Odori, Toru Kusakabe, Noriko Satoh-Asahara. Journal of diabetes investigation. 2020 May;11:653-661. [Full Text Article] [PubMed:31721467] [PMC:PMC7232283]
3
Recapitulation of anti-aging phenotypes by global overexpression of PTEN in mice. Mary Hager, Peter Chang, Michael Lee, Calvin M Burns, S Joseph Endicott, Richard A Miller, Xinna Li. GeroScience. 2024 April;46:2653-2670. [Full Text Article] [PubMed:38114855] [PMC:PMC10828233]

☰ Filters
Products
Proteins (24)
Over-Expression Lysate (2)
Recombinant (22)
FNDC5 / Irisin (24)
No (24)
6His, C-terminus (1)
6His, N-terminus (3)
6His-SUMO, N-terminus (1)
DDK (Flag) (1)
Fc, C-terminus (2)
GST (1)
GST, N-terminus (1)
His (3)
His, N-Terminal (3)
His,C-terminus (1)
Human IgG1 Fc (2)
Myc-DDK (Flag) (2)
Human (16)
293F Cells (2)
293T Cells (1)
CHO Cells (2)
E. coli (7)
HEK 293 Cells (3)
Human (3)
Human Cells (2)
Mammalian Cells (2)
Wheat Germ Extract (2)
Purified (5)
Low endotoxin level (13)
Biologically active (1)
FNDC5 / Irisin Protein - 12.5% SDS-PAGE of human FNDC5 stained with Coomassie Blue
Select
Wheat Germ Extract
GST
41.9 kDa
10 µg/$479; 25 µg/$670
Select
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
13.6kD
10 µg/$288; 50 µg/$442; 500 µg/$1,585; 1 mg/$2,157
Select
Human Cells
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
39.7kD
10 µg/$288; 50 µg/$442; 500 µg/$1,585; 1 mg/$2,157
FNDC5 / Irisin Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
Select
Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
FNDC5 / Irisin Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
15.3 kDa
20 µg/$150
FNDC5 / Irisin Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
15.3 kDa
100 µg/$494
FNDC5 / Irisin Protein - Recombinant Human/Mouse/Rat Irisin/FNDC5 (N-6His)
Select
Human
6His, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
13.4 kDa
10 µg/$327; 50 µg/$574
Select
Human
6His, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
13.4 kDa
10 µg/$327; 50 µg/$574
Select
Human
6His, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
13.4 kDa
10 µg/$327; 50 µg/$574
Select
Mammalian Cells
His,C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
13.6 kDa
10 µg/$288; 50 µg/$436
Select
Mammalian Cells
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
39.7 kDa
10 µg/$288; 50 µg/$436
FNDC5 / Irisin Protein - Eukaryotic Fibronectin Type III Domain Containing Protein 5 (FNDC5) by SDS-PAGE
Select
293F Cells
His, N-Terminal
16kDa
10 µg/$283; 50 µg/$452; 200 µg/$902; 100 µg/$722; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204
FNDC5 / Irisin Protein - Active Fibronectin Type III Domain Containing Protein 5 (FNDC5) by WB
Select
293F Cells
His, N-Terminal
16kDa
10 µg/$319; 50 µg/$677; 200 µg/$1,263; 100 µg/$1,065; 1 mg/$2,516; 500 µg/$2,016; 5 mg/$4,725; 2 mg/$2,708
Select
CHO Cells
None
Biologically active
25.2 kDa or 28 kDa
10 µg/$349; 2 µg/$268
FNDC5 / Irisin Protein - Active Fibronectin Type III Domain Containing Protein 5 (FNDC5) by WB
Select
E. coli
His, N-Terminal
18kDa
10 µg/$295; 50 µg/$530; 200 µg/$1,045; 100 µg/$847; 1 mg/$2,211; 500 µg/$1,728; 5 mg/$3,697; 2 mg/$2,402
Select
E. coli
152 AA
His
Less than 0.1 EU/µg protein (determined by LAL method).
16.83 kDa
10 mg/$4,268; 5 mg/$3,201; 1 mg/$1,868; 0.5 mg/$1,475; 200 µg/$1,103; 100 µg/$756; 50 µg/$531
Select
HEK 293 Cells
Human IgG1 Fc
Less than 0.01 EU/µg protein (determined by LAL method).
~50kDa
10 µg/$302
Select
HEK 293 Cells
Human IgG1 Fc
Less than 0.01 EU/µg protein (determined by LAL method).
~52kDa
10 µg/$379
Select
E. coli
None
Less than 0.01 EU/µg protein (determined by LAL method).
~16kDa
10 µg/$337
Select
CHO Cells
DDK (Flag)
Less than 0.01 EU/µg protein (determined by LAL method).
~26kDa
10 µg/$456
Select
E. coli
None
Less than 0.1 EU/µg protein (determined by LAL method).
~12kDa
10 µg/$337
FNDC5 / Irisin Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
E. coli
6His-SUMO, N-terminus
1 mg/$1,355; 100 µg/$420; 20 µg/$323
FNDC5 / Irisin Protein - Recombinant Fibronectin Type III Domain Containing Protein 5 By SDS-PAGE
Select
E. coli
His
9.3 kDa
10 µg/$281; 50 µg/$440; 100 µg/$702; 200 µg/$877; 1 mg/$1,983; 500 µg/$1,523; 5 mg/$3,067; 2 mg/$2,170
FNDC5 / Irisin Protein - Recombinant Fibronectin Type III Domain Containing Protein 5 By SDS-PAGE
Select
E. coli
His
16.9 kDa
10 µg/$281; 50 µg/$440; 100 µg/$702; 200 µg/$877; 1 mg/$1,983; 500 µg/$1,523; 5 mg/$3,067; 2 mg/$2,170
Viewing 1-24 of 24 product results


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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).