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FNDC5 / Irisin

fibronectin type III domain containing 5

FNDC5 / Irisin is a secreted protein that is released from muscle cells during exercise. The encoded protein may participate in the development of brown fat. Translation of the precursor protein initiates at a non-AUG start codon at a position that is conserved as an AUG start codon in other organisms. Alternative splicing results in multiple transcript variants.

Gene Name: fibronectin type III domain containing 5
Synonyms: FNDC5, Irisin, FRCP2
Target Sequences: Q8NAU1 Q8NAU1

Publications (3)

1
Hypergravity as a gravitational therapy mitigates the effects of knee osteoarthritis on the musculoskeletal system in a murine model. Benoit Dechaumet, Damien Cleret, Marie-Thérèse Linossier, Arnaud Vanden-Bossche, Stéphanie Chanon, Etienne Lefai, Norbert Laroche, Marie-Hélène Lafage-Proust, Laurence Vico. PloS one. 2020 December;15:e0243098. [Full Text Article] [PubMed:33296408] [PMC:PMC7725345]
2
Effects of dapagliflozin on the serum levels of fibroblast growth factor 21 and myokines and muscle mass in Japanese patients with type 2 diabetes: A randomized, controlled trial. Hajime Yamakage, Masashi Tanaka, Takayuki Inoue, Shinji Odori, Toru Kusakabe, Noriko Satoh-Asahara. Journal of diabetes investigation. 2020 May;11:653-661. [Full Text Article] [PubMed:31721467] [PMC:PMC7232283]
3
Recapitulation of anti-aging phenotypes by global overexpression of PTEN in mice. Mary Hager, Peter Chang, Michael Lee, Calvin M Burns, S Joseph Endicott, Richard A Miller, Xinna Li. GeroScience. 2024 April;46:2653-2670. [Full Text Article] [PubMed:38114855] [PMC:PMC10828233]

☰ Filters
Products
Antibodies (22)
Primary (22)
FNDC5 / Irisin (22)
Human (22)
Mouse (3)
Rat (2)
IHC (1)
IHC-P (2)
WB (20)
ELISA (3)
Peptide-ELISA (1)
rabbit (21)
mouse (1)
IgG (4)
IgG1,k (1)
monoclonal mc (1)
polyclonal pc (21)
1736CT532.85.53.92 (1)
APC (2)
APC Conjugated (2)
Biotin Conjugated (2)
Cy3 Conjugated (2)
Cy7 Conjugated (2)
FITC Conjugated (2)
HRP Conjugated (2)
PE Conjugated (2)
Preservative Free (1)
Unconjugated (8)
aa2-137 (8)
aa77-144 (8)
No (22)
FNDC5 / Irisin Antibody - Anti-FNDC5 Antibody at 1:2000 dilution + human skeletal muscle lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-mouse IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size: 23 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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FNDC5 / Irisin Mouse anti-Human Monoclonal (1736CT532.85.53.92) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$393
FNDC5 / Irisin Antibody - Western blot of FNDC5 / Irisin antibody.
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FNDC5 / Irisin Rabbit anti-Human Polyclonal (aa77-144) Antibody
Human
WB
Unconjugated
100 µl/$319; 200 µl/$365; 500 µl/$519; 1 ml/$597; 2 ml/$826; 5 ml/$1,352
FNDC5 / Irisin Antibody - Western blot of FNDC5 / Irisin antibody.
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FNDC5 / Irisin Rabbit anti-Human Polyclonal (aa77-144) (HRP) Antibody
Human
WB
HRP Conjugated
100 µl/$351; 200 µl/$411; 500 µl/$618; 1 ml/$774; 2 ml/$1,010; 5 ml/$1,757
FNDC5 / Irisin Antibody - Western blot of FNDC5 / Irisin antibody.
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FNDC5 / Irisin Rabbit anti-Human Polyclonal (aa77-144) (Biotin) Antibody
Human
WB
Biotin Conjugated
100 µl/$329; 200 µl/$381; 500 µl/$550; 1 ml/$654; 2 ml/$890; 5 ml/$1,487
FNDC5 / Irisin Antibody - Western blot of FNDC5 / Irisin antibody.
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FNDC5 / Irisin Rabbit anti-Human Polyclonal (aa77-144) (FITC) Antibody
Human
WB
FITC Conjugated
100 µl/$362; 200 µl/$427; 500 µl/$666; 1 ml/$826; 2 ml/$1,067; 5 ml/$1,892
FNDC5 / Irisin Antibody - Western blot of FNDC5 / Irisin antibody.
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FNDC5 / Irisin Rabbit anti-Human Polyclonal (aa77-144) (Cy3) Antibody
Human
WB
Cy3 Conjugated
100 µl/$427; 200 µl/$519; 500 µl/$916; 1 ml/$1,084; 2 ml/$1,441; 5 ml/$2,703
FNDC5 / Irisin Antibody - Western blot of FNDC5 / Irisin antibody.
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FNDC5 / Irisin Rabbit anti-Human Polyclonal (aa77-144) (PE) Antibody
Human
WB
PE Conjugated
100 µl/$427; 200 µl/$519; 500 µl/$916; 1 ml/$1,084; 2 ml/$1,441; 5 ml/$2,703
FNDC5 / Irisin Antibody - Western blot of FNDC5 / Irisin antibody.
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FNDC5 / Irisin Rabbit anti-Human Polyclonal (aa77-144) (APC) Antibody
Human
WB
APC Conjugated
100 µl/$427; 200 µl/$519; 500 µl/$916; 1 ml/$1,084; 2 ml/$1,441; 5 ml/$2,703
FNDC5 / Irisin Antibody - Western blot of FNDC5 / Irisin antibody.
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FNDC5 / Irisin Rabbit anti-Human Polyclonal (aa77-144) (APC, Cy7) Antibody
Human
WB
APC, Cy7 Conjugated
100 µl/$535; 200 µl/$714; 500 µl/$1,236; 1 ml/$1,545; 2 ml/$2,163; 5 ml/$4,053
FNDC5 / Irisin Antibody - Immunochemical staining FNDC5 in human kidney with rabbit polyclonal antibody at 1:1000 dilution, formalin-fixed paraffin embedded sections.
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FNDC5 / Irisin Rabbit anti-Mouse Polyclonal (Preservative Free) Antibody
Mouse, Rat, Human
IHC-P
Unconjugated, Preservative Free
20 µl/$256; 100 µl/$412
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FNDC5 / Irisin Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$341
FNDC5 / Irisin Antibody - Western blot analysis of FNDC5 using anti-FNDC5 antibody. Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours. The sample well of each lane was loaded with 50ug of sample under reducing conditions. Lane 1: rat heart tissue lysates, Lane 2: mouse heart tissue lysates. After Electrophoresis, proteins were transferred to a Nitrocellulose membrane at 150mA for 50-90 minutes. Blocked the membrane with 5% Non-fat Milk/ TBS for 1.5 hour at RT. The membrane was incubated with rabbit anti-FNDC5 antigen affinity purified polyclonal antibody at 0.5 ?g/mL overnight at 4?C, then washed with TBS-0.1% Tween 3 times with 5 minutes each and probed with a goat anti-rabbit IgG-HRP secondary antibody at a dilution of 1:10000 for 1.5 hour at RT. The signal is developed using an Enhanced Chemiluminescent detection (ECL) kit with Tanon 5200 system. A specific band was detected for FNDC5 at approximately 23KD. The expected band size for FNDC5 is at 23KD.
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FNDC5 / Irisin Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
10 µg/$318; 100 µg/$470
FNDC5 / Irisin Antibody - Western blot analysis of extracts of mouse liver tissue using FNDC5 antibody. The lane on the left was treated with blocking peptide.
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FNDC5 / Irisin Rabbit anti-Human Polyclonal Antibody
Mouse, Human
Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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FNDC5 / Irisin Rabbit anti-Human Polyclonal Antibody
Human
IHC, IHC-P
Unconjugated
100 µl/$412
FNDC5 / Irisin Antibody - Western blot of recombinant FNDC5.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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FNDC5 / Irisin Rabbit anti-Human Polyclonal (aa2-137) Antibody
Human
WB
Unconjugated
100 µl/$319; 200 µl/$365; 500 µl/$519; 1 ml/$597; 2 ml/$826; 5 ml/$1,352
FNDC5 / Irisin Antibody - Western blot of recombinant FNDC5.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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FNDC5 / Irisin Rabbit anti-Human Polyclonal (aa2-137) (HRP) Antibody
Human
WB
HRP Conjugated
100 µl/$351; 200 µl/$411; 500 µl/$618; 1 ml/$774; 2 ml/$1,010; 5 ml/$1,757
FNDC5 / Irisin Antibody - Western blot of recombinant FNDC5.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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FNDC5 / Irisin Rabbit anti-Human Polyclonal (aa2-137) (Biotin) Antibody
Human
WB
Biotin Conjugated
100 µl/$329; 200 µl/$381; 500 µl/$550; 1 ml/$654; 2 ml/$890; 5 ml/$1,487
FNDC5 / Irisin Antibody - Western blot of recombinant FNDC5.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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FNDC5 / Irisin Rabbit anti-Human Polyclonal (aa2-137) (FITC) Antibody
Human
WB
FITC Conjugated
100 µl/$362; 200 µl/$427; 500 µl/$666; 1 ml/$826; 2 ml/$1,067; 5 ml/$1,892
FNDC5 / Irisin Antibody - Western blot of recombinant FNDC5.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
FNDC5 / Irisin Rabbit anti-Human Polyclonal (aa2-137) (Cy3) Antibody
Human
WB
Cy3 Conjugated
100 µl/$427; 200 µl/$519; 500 µl/$916; 1 ml/$1,084; 2 ml/$1,441; 5 ml/$2,703
FNDC5 / Irisin Antibody - Western blot of recombinant FNDC5.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
FNDC5 / Irisin Rabbit anti-Human Polyclonal (aa2-137) (PE) Antibody
Human
WB
PE Conjugated
100 µl/$427; 200 µl/$519; 500 µl/$916; 1 ml/$1,084; 2 ml/$1,441; 5 ml/$2,703
FNDC5 / Irisin Antibody - Western blot of recombinant FNDC5.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
FNDC5 / Irisin Rabbit anti-Human Polyclonal (aa2-137) (APC) Antibody
Human
WB
APC Conjugated
100 µl/$427; 200 µl/$519; 500 µl/$916; 1 ml/$1,084; 2 ml/$1,441; 5 ml/$2,703
FNDC5 / Irisin Antibody - Western blot of recombinant FNDC5.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
FNDC5 / Irisin Rabbit anti-Human Polyclonal (aa2-137) (APC, Cy7) Antibody
Human
WB
APC, Cy7 Conjugated
100 µl/$535; 200 µl/$714; 500 µl/$1,236; 1 ml/$1,545; 2 ml/$2,163; 5 ml/$4,053
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).