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May act as a link between RND2 signaling and regulation of the actin cytoskeleton (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during the late stage of clathrin-mediated endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also enhances actin polymerization via the recruitment of WASL/N-WASP, which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. May be required for the lysosomal retention of FASLG/FASL.
Gene Name: | formin binding protein 1 |
Synonyms: | FNBP1, FBP17, HFBP17, KIAA0554, Formin-binding protein 1, Formin-binding protein 17, Formin binding protein 1 |
Target Sequences: | AB011126 BAA25480.1 Q96RU3 |
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