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Fibromodulin belongs to the family of small interstitial proteoglycans. The encoded protein possesses a central region containing leucine-rich repeats with 4 keratan sulfate chains, flanked by terminal domains containing disulphide bonds. Owing to the interaction with type I and type II collagen fibrils and in vitro inhibition of fibrillogenesis, the encoded protein may play a role in the assembly of extracellular matrix. It may also regulate TGF-beta activities by sequestering TGF-beta into the extracellular matrix. Sequence variations in this gene may be associated with the pathogenesis of high myopia. Alternative splicing results in multiple transcript variants.
Gene Name: | fibromodulin |
Synonyms: | FMOD, Fibromodulin, Fibromodulin proteoglycan, FM, KSPG fibromodulin, SLRR2E |
Target Sequences: | NM_002023 NP_002014.2 Q06828 |
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