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FLVCR2 is a member of the major facilitator superfamily. The encoded transmembrane protein is a calcium transporter. Unlike the related protein feline leukemia virus subgroup C receptor 1, the protein encoded by this locus does not bind to feline leukemia virus subgroup C envelope protein. The encoded protein may play a role in development of brain vascular endothelial cells, as mutations at this locus have been associated with proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome. Alternatively spliced transcript variants have been described.
Gene Name: | feline leukemia virus subgroup C cellular receptor family, member 2 |
Synonyms: | FLVCR2, C14orf58, Calcium-chelate transporter, CCT, FLVCRL14q, EPV, PVHH, MFSD7C |
Target Sequences: | NM_017791 NP_060261.2 Q9UPI3 |
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