FLT4 / VEGFR3

fms-related tyrosine kinase 4

Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development. Promotes proliferation, survival and migration of endothelial cells, and regulates angiogenic sprouting. Signaling by activated FLT4 leads to enhanced production of VEGFC, and to a lesser degree VEGFA, thereby creating a positive feedback loop that enhances FLT4 signaling. Modulates KDR signaling by forming heterodimers. The secreted isoform 3 may function as a decoy receptor for VEGFC and/or VEGFD and play an important role as a negative regulator of VEGFC-mediated lymphangiogenesis and angiogenesis. Binding of vascular growth factors to isoform 1 or isoform 2 leads to the activation of several signaling cascades; isoform 2 seems to be less efficient in signal transduction, because it has a truncated C-terminus and therefore lacks several phosphorylation sites. Mediates activation of the MAPK1/ERK2, MAPK3/ERK1 signaling pathway, of MAPK8 and the JUN signaling pathway, and of the AKT1 signaling pathway. Phosphorylates SHC1. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Promotes phosphorylation of MAPK8 at 'Thr-183' and 'Tyr-185', and of AKT1 at 'Ser-473'.

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Products

Proteins (8)

Type

Over-Expression Lysate (2)

Recombinant (6)

Target

FLT4 / VEGFR3 (8)

Publications

No (8)

Tag

Fc (2)

GST, N-terminus (1)

His (3)

Myc-DDK (Flag) (2)

Species

Human (4)

Mouse (3)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (1)

Human Cells (4)

Wheat Germ Extract (1)

Purification

Purified (4)

Low Endotoxin Level

Low endotoxin level (4)

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Mouse FLT4 / VEGFR3 Protein (Recombinant His) (aa30-326) - LS-G14435

Source:

E. coli

Tag:

His

Molecular Weight:

35.0 kDa

Price:

10 µg/$279; 50 µg/$432; 100 µg/$690; 200 µg/$862; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148

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Human FLT4 / VEGFR3 Protein (Recombinant GST, N-terminus) (aa34-133) - LS-G58593

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human FLT4 / VEGFR3 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G76001

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

150.2 kDa

Price:

20 µg/$215

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Human FLT4 / VEGFR3 Protein (Recombinant His) (Met1-Ile776) - LS-G98013

Source:

Human Cells

Tag:

His

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

86 kDa

Price:

100 µg/$721

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Human FLT4 / VEGFR3 Protein (Recombinant Fc) (Met1-Ile776) - LS-G98015

Source:

Human Cells

Tag:

Fc

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

111 kDa

Price:

100 µg/$721

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Mouse FLT4 / VEGFR3 Protein (Recombinant His) (Met1-Glu775) - LS-G98782

Source:

Human Cells

Tag:

His

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

86.4 kDa

Price:

100 µg/$793; 1 mg/$4,191

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Mouse FLT4 / VEGFR3 Protein (Recombinant Fc) (Met1-Glu775) - LS-G98783

Source:

Human Cells

Tag:

Fc

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

112 kDa

Price:

100 µg/$793

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FLT4 / VEGFR3 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G104078

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

150.2 kDa

Price:

100 µg/$710

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