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FLNA / Filamin A

filamin A, alpha

FLNA / Filamin A is an actin-binding protein that crosslinks actin filaments and links actin filaments to membrane glycoproteins. The encoded protein is involved in remodeling the cytoskeleton to effect changes in cell shape and migration. This protein interacts with integrins, transmembrane receptor complexes, and second messengers. Defects in this gene are a cause of several syndromes, including periventricular nodular heterotopias (PVNH1, PVNH4), otopalatodigital syndromes (OPD1, OPD2), frontometaphyseal dysplasia (FMD), Melnick-Needles syndrome (MNS), and X-linked congenital idiopathic intestinal pseudoobstruction (CIIPX). Two transcript variants encoding different isoforms have been found for this gene.

Gene Name: filamin A, alpha
Synonyms: FLNA, ABPX, Actin binding protein 280, Actin-binding protein 280, Filamin A, FLN1, FMD, Filamin-A, Filamin-1, FLN, FLN-A, Non-muscle filamin, OPD1, OPD2, Alpha-filamin, NHBP, OPD, XMVD, CVD1, Filamin A, alpha, MNS, XLVD
Target Sequences: NM_001456 NP_001447.2 P21333

Publications (2)

1
Potential Utility of Protein Targets of Cysteine-S-Nitrosylation in Identifying Clinical Disease Status in Human Chagas Disease. Maria Paola Zago, John E Wiktorowicz, Heidi Spratt, Sue-Jie Koo, Natalia Barrientos, Aida Nuñez Burgos, Julio Nuñez Burgos, Facundo Iñiguez, Valentina Botelli, Ricardo Leon de la Fuente, Nisha Jain Garg. Frontiers in microbiology. 2019 January;9:3320. [Full Text Article] [PubMed:30697201] [PMC:PMC6340995]
2
High Filamin a Expression in Adrenocortical Carcinomas Is Associated with a Favourable Tumour Behaviour: A European Multicentric Study. Rosa Catalano, Barbara Altieri, Anna Angelousi, Maura Arosio, Francesca Bravi, Letizia Canu, Giorgio A Croci, Mario Detomas, Emanuela Esposito, Emanuele Ferrante, Stefano Ferrero, Carmina T Fuss, Gregory Kaltsas, Otilia Kimpel, Laura-Sophie Landwehr, Michaela Luconi, Valentina Morelli, Gabriella Nesi, Emma Nozza, Silviu Sbiera, Andreea L Serban, Cristina L Ronchi, Giovanna Mantovani, Erika Peverelli. International journal of molecular sciences. 2023 November;24: [Full Text Article] [PubMed:38068896] [PMC:PMC10706064] Related Antibodies: LS-B4865.

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FLNA / Filamin A (68)
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FLNA / Filamin A Antibody - Anti-FLNA / FMD antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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FLNA / Filamin A Rabbit anti-Human Polyclonal Antibody
Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$485
FLNA / Filamin A Antibody - Anti-FLNA / FMD antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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FLNA / Filamin A Mouse anti-Human Monoclonal (4E10-1B2) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$440
FLNA / Filamin A Antibody - Anti-FLNA / FMD antibody IHC of human uterus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
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FLNA / Filamin A Rabbit anti-Human Polyclonal (aa2121-2170) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$460
FLNA / Filamin A Antibody - Immunohistochemical analysis of Filamin A staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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FLNA / Filamin A Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Rabbit, Mouse, Rat, Human
IHC, IHC-P, IP, WB
Unconjugated
100 µl/$299
FLNA / Filamin A ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
1.88 - 120 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$730
FLNA / Filamin A Protein - Purified recombinant protein FLNA was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
280.6 kDa
20 µg/$1,107
FLNA / Filamin A Antibody - Staining 293 cells by IF/ICC. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 min at 25°C. The primary antibody was diluted at 1:200 and incubated with the sample for 1 hour at 37°C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) Ab, diluted at 1/600, was used as the secondary antibody.
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FLNA / Filamin A Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
FLNA / Filamin A ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
FLNA / Filamin A Protein - Recombinant  Filamin A Alpha By SDS-PAGE
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E. coli
6His-T7, N-terminus
34.3 kDa
10 µg/$280; 50 µg/$437; 100 µg/$700; 200 µg/$872; 1 mg/$1,978; 500 µg/$1,519; 5 mg/$3,053; 2 mg/$2,164
FLNA / Filamin A Antibody - Immunohistochemistry of paraffin-embedded human oophoroma tissue.
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FLNA / Filamin A Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
FLNA / Filamin A Antibody - Detection of Human Filamin A by Immunohistochemistry. Sample: FFPE section of human colon carcinoma. Antibody: Affinity purified rabbit anti-Filamin A used at a dilution of 1:1000 (0.2 Detection: DAB.
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FLNA / Filamin A Rabbit anti-Human Polyclonal (aa400-450) Antibody
Human
IHC, WB
Unconjugated
10 µl/$295; 100 µl/$514
FLNA / Filamin A Antibody - 1:200 staining mouse testis tissue by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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FLNA / Filamin A Rabbit anti-Human Polyclonal (pSer2152) Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
FLNA / Filamin A Antibody - Sample (30 ug of whole cell lysate) A: A431 5% SDS PAGE FLNA / FMD antibody diluted at 1:1000
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FLNA / Filamin A Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
WB
Unconjugated
100 µl/$450
FLNA / Filamin A Antibody - Detection of Human Filamin A by Immunohistochemistry. Sample: FFPE section of human colon carcinoma. Antibody: Affinity purified rabbit anti-Filamin A used at a dilution of 1:250.
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FLNA / Filamin A Rabbit anti-Human Polyclonal (aa1725-1775) Antibody
Human
IF, IHC
Unconjugated
0.5 µg/$295; 100 µl/$532
FLNA / Filamin A Antibody - Immunohistochemistry of paraffin-embedded Rat heart using FLNA Polyclonal Antibody at dilution of 1:100 (40x lens).
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FLNA / Filamin A Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
FLNA / Filamin A ELISA Kit
Select
Sandwich
12 x 8-Well Microstrips
Mouse
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
FLNA / Filamin A Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
279.8 kDa
20 µg/$215
FLNA / Filamin A Antibody - Immunohistochemistry of paraffin-embedded Human colon cancer using FLNA Polyclonal Antibody at dilution of 1:50.
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FLNA / Filamin A Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
FLNA / Filamin A Antibody - Immunohistochemistry of paraffin-embedded Human liver cancer using FLNA Polyclonal Antibody at dilution of 1:40.
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FLNA / Filamin A Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
FLNA / Filamin A Antibody - Immunohistochemical analysis of Filamin A (pS2152) staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
Select
FLNA / Filamin A Rabbit anti-Human Polyclonal (pSer2152) Antibody
Rat, Human
IHC, IHC-P, IP, WB
Unconjugated
100 µl/$315
FLNA / Filamin A Antibody - Immunohistochemistry analysis of paraffin-embedded human breast carcinoma, using Filamin A (Phospho-Ser2152) Antibody. The picture on the right is blocked with the phospho peptide.
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FLNA / Filamin A Rabbit anti-Human Polyclonal (pSer2152) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
FLNA / Filamin A Antibody - Immunofluorescence analysis of HeLa cells using FLNA antibody at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.
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FLNA / Filamin A Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, IP, WB
Unconjugated
20 µl/$275; 100 µl/$389
FLNA / Filamin A Antibody - Western blot of Phospho-Filamin 1 (S2152) antibody
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FLNA / Filamin A Rabbit anti-Human Polyclonal (2090-2170 aa) Antibody
Mouse, Rat, Human, Monkey
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
FLNA / Filamin A Antibody - Detection of Human Filamin A by Immunohistochemistry. Sample: FFPE section of human colon carcinoma. Antibody: Affinity purified rabbit anti-Filamin A used at a dilution of 1:1000 (0.2 Detection: DAB.
Select
FLNA / Filamin A Rabbit anti-Human Polyclonal (aa1725-1775) Antibody
Mouse, Human
IHC, IP, WB
Unconjugated
10 µl/$295; 100 µl/$514
FLNA / Filamin A Antibody - Detection of Human Filamin A by Immunohistochemistry. Sample: FFPE section of human colon carcinoma. Antibody: Affinity purified rabbit anti-Filamin A used at a dilution of 1:1000 (0.2 Detection: DAB.
Select
FLNA / Filamin A Rabbit anti-Human Polyclonal (aa2597-2647) Antibody
Mouse, Human
IHC, IP, WB
Unconjugated
10 µl/$295; 100 µl/$514
Viewing 1-25 of 68 product results



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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).