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Location
Corporate Headquarters
Vector Laboratories, Inc.
6737 Mowry Ave
Newark, CA 94560
United States
Telephone Numbers
Customer Service: (800) 227-6666 / (650) 697-3600
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FKBP4 / FKBP52
FK506 binding protein 4, 59kDa
FKBP4 / FKBP52 is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It has high structural and functional similarity to FK506-binding protein 1A (FKBP1A), but unlike FKBP1A, this protein does not have immunosuppressant activity when complexed with FK506. It interacts with interferon regulatory factor-4 and plays an important role in immunoregulatory gene expression in B and T lymphocytes. This encoded protein is known to associate with phytanoyl-CoA alpha-hydroxylase. It can also associate with two heat shock proteins (hsp90 and hsp70) and thus may play a role in the intracellular trafficking of hetero-oligomeric forms of the steroid hormone receptors. This protein correlates strongly with adeno-associated virus type 2 vectors (AAV) resulting in a significant increase in AAV-mediated transgene expression in human cell lines. Thus this encoded protein is thought to have important implications for the optimal use of AAV vectors in human gene therapy. The human genome contains several non-transcribed pseudogenes similar to this gene.
| Gene Name: | FK506 binding protein 4, 59kDa |
| Synonyms: | FKBP4, 59 kDa immunophilin, 51 kDa FK506-binding protein, 52 kDa FK506-binding protein, 52 kDa FKBP, FKBP-52, FKBP51, HBI, Immunophilin FKBP52, FK506 binding protein 4, 59kDa, FK506-binding protein 4, HSP56, p52, p59, Rotamase, p59 protein, PPIase, PPIase FKBP4, FKBP-4, FKBP52, FKBP59, HSP binding immunophilin, HSP-binding immunophilin |
| Target Sequences: | NM_002014 NP_002005.1 Q02790 |
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