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FKBP1A / FKBP12

FK506 binding protein 1A, 12kDa

FKBP1A / FKBP12 is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. It also interacts with multiple intracellular calcium release channels, and coordinates multi-protein complex formation of the tetrameric skeletal muscle ryanodine receptor. In mouse, deletion of this homologous gene causes congenital heart disorder known as noncompaction of left ventricular myocardium. Multiple alternatively spliced variants, encoding the same protein, have been identified. The human genome contains five pseudogenes related to this gene, at least one of which is transcribed.

Gene Name: FK506 binding protein 1A, 12kDa
Synonyms: FKBP1A, 12 kDa FKBP, 12 kDa FK506-binding protein, Calstabin-1, FK506 binding protein12, Fk506-binding protein, FKBP12C, FK506-binding protein 12, FKBP-1A, Immunophilin FKBP12, FK506-binding protein 1, FKBP1, FKBP12-Exip3, PKC12, PKCI2, PPIase FKBP1A, Protein kinase C inhibitor 2, Rotamase, PPIase, FK506-binding protein 1A, FKBP-12
Target Sequences: NM_000801 NP_000792.1 P62942

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Products
Proteins (13)
Over-Expression Lysate (4)
Recombinant (9)
FKBP1A / FKBP12 (13)
No (13)
GST (1)
His (6)
Myc-DDK (Flag) (6)
Bovine (1)
Human (8)
Mouse (2)
293T Cells (2)
E. coli (6)
HEK 293 Cells (4)
Wheat Germ Extract (1)
Purified (3)
Low endotoxin level (1)
Biologically active (1)
FKBP1A / FKBP12 Protein
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E. coli
His
100 µg/$361; 500 µg/$739; 20 µg/$261
FKBP1A / FKBP12 Protein
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E. coli
His
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
100 µg/$342; 500 µg/$641; 20 µg/$254
FKBP1A / FKBP12 Protein - Purified recombinant protein FKBP1A was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
11.8 kDa
20 µg/$1,107
FKBP1A / FKBP12 Protein - Purified recombinant protein FKBP1A was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
11.8 kDa
20 µg/$1,107
FKBP1A / FKBP12 Protein - 12.5% SDS-PAGE of human FKBP1A stained with Coomassie Blue
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Wheat Germ Extract
GST
37.62 kDa
10 µg/$479; 25 µg/$670
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E. coli
His
12.9 kDa
100 µg/$443
Select
E. coli
His
12.7 kDa
100 µg/$532
Select
293T Cells
Myc-DDK (Flag)
11.8 kDa
20 µg/$150
Select
293T Cells
Myc-DDK (Flag)
11.8 kDa
20 µg/$150
FKBP1A / FKBP12 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
11.8 kDa
100 µg/$494
FKBP1A / FKBP12 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
11.8 kDa
100 µg/$494
FKBP1A / FKBP12 Protein - Recombinant FK506 Binding Protein 1A By SDS-PAGE
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E. coli
His
13.2 kDa
10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176
FKBP1A / FKBP12 Protein - Recombinant FK506 Binding Protein 1A By SDS-PAGE
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E. coli
His
13.3 kDa
10 µg/$262; 50 µg/$339; 100 µg/$512; 200 µg/$642; 1 mg/$1,623; 500 µg/$1,214; 5 mg/$2,562; 2 mg/$1,796
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).