FGFR4

fibroblast growth factor receptor 4

Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes SRC-dependent phosphorylation of the matrix protease MMP14 and its lysosomal degradation. FGFR4 signaling is down-regulated by receptor internalization and degradation; MMP14 promotes internalization and degradation of FGFR4. Mutations that lead to constitutive kinase activation or impair normal FGFR4 inactivation lead to aberrant signaling.

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Products

Proteins (22)

Type

Over-Expression Lysate (10)

Recombinant (12)

Target

FGFR4 (22)

Publications

No (22)

Tag

DDK (Flag)-His, C-terminus (1)

Fc (1)

Fc, C-terminus (1)

GST (1)

GST, N-terminus (1)

His (2)

His,C-terminus (1)

His-Fc (1)

His-T7 (2)

Myc-DDK (Flag) (11)

Species

Human (12)

Mouse (3)

Rat (2)

Source

293T Cells (5)

E. coli (2)

HEK 293 Cells (9)

Human Cells (4)

Wheat Germ Extract (2)

Purification

Purified (5)

Low Endotoxin Level

Low endotoxin level (6)

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Human FGFR4 Protein (Recombinant His-T7) (aa168-369) - LS-G14296

Source:

E. coli

Tag:

His-T7

Molecular Weight:

26.1 kDa

Price:

10 µg/$279; 50 µg/$432; 100 µg/$690; 200 µg/$862; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148

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Human FGFR4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G75916

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

87.95 kDa

Price:

20 µg/$150

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Human FGFR4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G75917

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

80.9 kDa

Price:

20 µg/$215

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Human FGFR4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G75918

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

80.9 kDa

Price:

20 µg/$215

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Human FGFR4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G75919

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

85.5 kDa

Price:

20 µg/$215

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Human FGFR4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G75920

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

85.5 kDa

Price:

20 µg/$215

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FGFR4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G110145

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

80.9 kDa

Price:

100 µg/$710

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FGFR4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G102669

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

85.5 kDa

Price:

100 µg/$710

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FGFR4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G127794

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

85.5 kDa

Price:

100 µg/$710

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Mouse FGFR4 Protein (Recombinant His-T7) (aa165-366) - LS-G24500

Source:

E. coli

Tag:

His-T7

Molecular Weight:

26.2 kDa

Price:

10 µg/$283; 50 µg/$457; 100 µg/$732; 200 µg/$912; 1 mg/$2,032; 500 µg/$1,567; 5 mg/$3,193; 2 mg/$2,219

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Human FGFR4 Protein (Recombinant GST, N-terminus) (aa31-145) - LS-G58565

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human FGFR4 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G65628

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

80.9 kDa

Price:

20 µg/$1,107

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FGFR4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G127191

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

80.9 kDa

Price:

100 µg/$710

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Human FGFR4 Protein (Recombinant Fc, C-terminus) (Met1-Asp369) - LS-G138086

Source:

HEK 293 Cells

Tag:

Fc, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

66 kDa

Price:

100 µg/$721

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Rat FGFR4 Protein (Recombinant His,C-terminus) (Met1-Asp367) - LS-G138222

Source:

HEK 293 Cells

Tag:

His,C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

40.3 kDa

Price:

100 µg/$721

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Human FGFR4 Protein (Recombinant DDK (Flag)-His, C-terminus) - LS-G142204

Source:

HEK 293 Cells

Tag:

DDK (Flag)-His, C-terminus

Molecular Weight:

41 kDa

Price:

20 µg/$1,107

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Mouse FGFR4 Protein (Recombinant His-Fc) (Met1-Asp366) - LS-G98151

Source:

Human Cells

Tag:

His-Fc

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

67 kDa

Price:

100 µg/$721

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Rat FGFR4 Protein (Recombinant Fc) (Met1-Asp367) - LS-G98395

Source:

Human Cells

Tag:

Fc

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

66 kDa

Price:

100 µg/$721

Select

Mouse FGFR4 Protein (Recombinant His) (Met1-Asp366) - LS-G98779

Source:

Human Cells

Tag:

His

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

40 kDa

Price:

100 µg/$843

Select

Human FGFR4 Protein (Recombinant His) (Met1-Asp369) - LS-G98580

Source:

Human Cells

Tag:

His

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

40 kDa

Price:

50 µg/$502

Select

FGFR4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G99618

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

87.95 kDa

Price:

100 µg/$494

Select

Human FGFR4 Protein (Recombinant GST) (Full Length) - LS-G28471

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

113.96 kDa

Price:

10 µg/$479; 25 µg/$670

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