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FGFR4

fibroblast growth factor receptor 4

Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes SRC-dependent phosphorylation of the matrix protease MMP14 and its lysosomal degradation. FGFR4 signaling is down-regulated by receptor internalization and degradation; MMP14 promotes internalization and degradation of FGFR4. Mutations that lead to constitutive kinase activation or impair normal FGFR4 inactivation lead to aberrant signaling.

Gene Name: fibroblast growth factor receptor 4
Family/Subfamily: Protein Kinase , FGF Receptor
Synonyms: FGFR4, CD334, CD334 antigen, Hydroxyaryl-protein kinase, FGFR-4, JTK2, TKF, Tyrosylprotein kinase, FGF receptor 4, Protein-tyrosine kinase
Target Sequences: NM_002011 NP_002002.3 P22455

☰ Filters
Products
Proteins (22)
Over-Expression Lysate (10)
Recombinant (12)
FGFR4 (22)
No (22)
DDK (Flag)-His, C-terminus (1)
Fc (1)
Fc, C-terminus (1)
GST (1)
GST, N-terminus (1)
His (2)
His,C-terminus (1)
His-Fc (1)
His-T7 (2)
Myc-DDK (Flag) (11)
Human (12)
Mouse (3)
Rat (2)
293T Cells (5)
E. coli (2)
HEK 293 Cells (9)
Human Cells (4)
Wheat Germ Extract (2)
Purified (5)
Low endotoxin level (6)
FGFR4 Protein - Recombinant Fibroblast Growth Factor Receptor 4 By SDS-PAGE
Select
E. coli
His-T7
26.1 kDa
10 µg/$279; 50 µg/$432; 100 µg/$690; 200 µg/$862; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148
FGFR4 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
Select
Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
FGFR4 Protein - Purified recombinant protein FGFR4 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
80.9 kDa
20 µg/$1,107
FGFR4 Protein - Recombinant  Fibroblast Growth Factor Receptor 4 By SDS-PAGE
Select
E. coli
His-T7
26.2 kDa
10 µg/$283; 50 µg/$457; 100 µg/$732; 200 µg/$912; 1 mg/$2,032; 500 µg/$1,567; 5 mg/$3,193; 2 mg/$2,219
FGFR4 Protein - 12.5% SDS-PAGE of human FGFR4 stained with Coomassie Blue
Select
Wheat Germ Extract
GST
113.96 kDa
10 µg/$479; 25 µg/$670
Select
Human Cells
His
Less than 1.0 EU/µg protein (determined by LAL method).
40 kDa
50 µg/$502
Select
Human Cells
His
Less than 1.0 EU/µg protein (determined by LAL method).
40 kDa
100 µg/$843
Select
293T Cells
Myc-DDK (Flag)
80.9 kDa
20 µg/$215
FGFR4 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
80.9 kDa
20 µg/$215
Select
293T Cells
Myc-DDK (Flag)
85.5 kDa
20 µg/$215
FGFR4 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
85.5 kDa
20 µg/$215
FGFR4 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
87.95 kDa
20 µg/$150
FGFR4 Protein
Select
HEK 293 Cells
DDK (Flag)-His, C-terminus
41 kDa
20 µg/$1,107
FGFR4 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
80.9 kDa
100 µg/$710
FGFR4 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
87.95 kDa
100 µg/$494
FGFR4 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
85.5 kDa
100 µg/$710
FGFR4 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
85.5 kDa
100 µg/$710
FGFR4 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
80.9 kDa
100 µg/$710
Select
HEK 293 Cells
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
66 kDa
100 µg/$721
Select
HEK 293 Cells
His,C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
40.3 kDa
100 µg/$721
Select
Human Cells
His-Fc
Less than 1.0 EU/µg protein (determined by LAL method).
67 kDa
100 µg/$721
Select
Human Cells
Fc
Less than 1.0 EU/µg protein (determined by LAL method).
66 kDa
100 µg/$721
Viewing 1-22 of 22 product results


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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).