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FGF3 is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified by its similarity with mouse fgf3/int-2, a proto-oncogene activated in virally induced mammary tumors in the mouse. Frequent amplification of this gene has been found in human tumors, which may be important for neoplastic transformation and tumor progression. Studies of the similar genes in mouse and chicken suggested the role in inner ear formation.
Gene Name: | fibroblast growth factor 3 |
Family/Subfamily: | HBGF , not assigned-HBGF |
Synonyms: | FGF3, FGF-3, Fibroblast growth factor 3, HBGF-3, Proto-oncogene Int-2, INT-2 proto-oncogene protein, INT2, Oncogene INT2 |
Target Sequences: | NM_005247 NP_005238.1 P11487 |
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