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FGF21

fibroblast growth factor 21

Stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression (but not SLC2A4/GLUT4 expression). Activity requires the presence of KLB.

Gene Name: fibroblast growth factor 21
Family/Subfamily: HBGF , not assigned-HBGF
Synonyms: FGF21, Fibroblast growth factor 21, FGF-21
Target Sequences: NM_019113 NP_061986.1 Q9NSA1

Publications (4)

1
Deficiency in interleukin-18 promotes differentiation of brown adipose tissue resulting in fat accumulation despite dyslipidemia. Yamanishi K, Maeda S, Kuwahara-Otani S, Hashimoto T, Ikubo K, Mukai K, Nakasho K, Gamachi N, El-Darawish Y, Li W, Okuzaki D, Watanabe Y, Yamanishi H, Okamura H, Matsunaga H. Journal of translational medicine. 2018 November;16:314. [Full Text Article] [PubMed:30453990] [PMC:PMC6245626] Related Antibodies: LS-B5864.
2
Relationship of HIV Status and Fatigue, Cardiorespiratory Fitness, Myokines, and Physical Activity. Allison R Webel, Trevor Jenkins, Christopher T Longenecker, Marianne Vest, Christine Horvat Davey, Jackson Currie, Rebecca Darrah, Paul Litman, Vitor Hugo Fernando de Oliveira, Richard A Josephson. The journal of the Association of Nurses in AIDS Care : JANAC. 2019 June;30:392-404. [Full Text Article] [PubMed:31241504] [PMC:PMC7179736]
3
Reversal of obesity-induced hypertriglyceridemia by (R)- alpha -lipoic acid in ZDF (fa/fa) rats. Yi X, Pashaj A, Xia M, Moreau R. Biochemical and biophysical research communications. 2013 Sep;439:390-5. [Full Text Article] [PubMed:23994635] Related Antibodies: LS-B5864.
4
Astragalus polysaccharides affect insulin resistance by regulating the hepatic SIRT1-PGC-1a/PPARa-FGF21 signaling pathway in male Sprague Dawley rats undergoing catch-up growth. Gu C, Zeng Y, Tang Z, Wang C, He Y, Feng X, Zhou L. Molecular medicine reports. 2015 12:6451-60. (WB; Rat) [Full Text Article] [PubMed:26323321] [PMC:PMC4626146] Related Antibodies: LS-B5864.
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Antibodies (109)
Primary (109)
FGF21 (109)
Human (81)
Mouse (29)
Rat (13)
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IHC (19)
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rabbit (65)
mouse (41)
goat (1)
rat (1)
sheep (1)
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IHCPlus (1)
IgG (27)
IgG1 (24)
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monoclonal mc (41)
polyclonal pc (68)
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aa29-209 (39)
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FGF21 Antibody - Anti-FGF21 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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FGF21 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
FGF21 Antibody - Immunoperoxidase of monoclonal antibody to FGF21 on formalin-fixed paraffin-embedded human tonsil. [antibody concentration 3 ug/ml]
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FGF21 Mouse anti-Human Monoclonal (2F11) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
100 µg/$423
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FGF21 Rabbit anti-Mouse Polyclonal Antibody
Mouse
ELISA, WB
Unconjugated
100 µg/$657
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FGF21 Rabbit anti-Human Polyclonal (aa184-209) Antibody
Human
ELISA
Unconjugated
200 µg/$1,027
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FGF21 Mouse anti-Human Monoclonal (aa29-209) Antibody
Human
ELISA, Flo, ICC
Unconjugated
100 µg/$896
FGF21 Antibody - Western blot analysis using anti-FGF-21 (human), mAb (FG224-7) at 1:2000 dilution. 1: Human FGF-21 Fc-protein. 2: Human FGF-21 (FLAG-tagged). 4: Mouse FGF-21 Fc protein. 5: Mouse FGF-21 (His-tagged). 6: Human FGF-21 (His-tagged) from competitor. 7: Human Jagged-1 Fc-protein (negative control).
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FGF21 Rat anti-Mouse Monoclonal (FG224-7) Antibody
Mouse, Human
ELISA, WB
Unconjugated
100 µg/$323
FGF21 Antibody - Western blot - Anti-FGF21 Picoband Antibody
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FGF21 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
10 µg/$318; 100 µg/$470
FGF21 Antibody - IHC of paraffin-embedded Human breast tissue using anti-FGF21 mouse monoclonal antibody.
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FGF21 Mouse anti-Human Monoclonal (OTI2F10) Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated
100 µl/$434
FGF21 Antibody - IHC of paraffin-embedded Human breast tissue using anti-FGF21 mouse monoclonal antibody.
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FGF21 Mouse anti-Human Monoclonal (aa29-209) (Carrier-free) (OTI2F10) Antibody
Human
Flo, IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
FGF21 Antibody - Antibody (1 ug/ml) staining of Human Liver lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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FGF21 Goat anti-Human Polyclonal (aa103-115) Antibody
Human, Monkey
Peptide-ELISA, WB
Unconjugated
100 µg/$503
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FGF21 Rabbit anti-Human Polyclonal (aa26-47) Antibody
Human
ELISA
Unconjugated
200 µg/$1,027
FGF21 Antibody - Immunohistochemical staining of human tissue using anti-FGF-21 (human), pAb at 1:5000 dilution. . 1. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human parathyroid (A), liver (B) and small intestine (C) (100-200x, brown color). 2. Staining with pre-immune rabbit serum (A-1, B-1, C-1) as negative control (1:500).
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FGF21 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IHC, IHC-P, WB
Unconjugated
100 µg/$386
FGF21 Antibody - Western blot analysis using anti-FGF-21 (mouse), pAb at 1:4000 dilution. 1: Mouse FGF-21 (FLAG-tagged). 2: Mouse FGF-21 Fc-protein. 3: Human FGF-21 (FLAG-tagged). 4: Mouse Nampt (FLAG-tagged) (negative control).
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FGF21 Rabbit anti-Mouse Polyclonal Antibody
Mouse
ELISA, WB
Unconjugated
100 µg/$323
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FGF21 Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
50 µg/$508
FGF21 Antibody - Immunohistochemistry of paraffin-embedded human prostate using FGF21 antibody at dilution of 1:100.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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FGF21 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$294; 100 µg/$360
FGF21 Antibody - Immunohistochemistry of paraffin-embedded human prostate using FGF21 antibody at dilution of 1:100.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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FGF21 Rabbit anti-Human Polyclonal (HRP) Antibody
Human
ELISA, IHC, IHC-P, WB
HRP Conjugated
50 µg/$294; 100 µg/$360
FGF21 Antibody - Anti-FGF21 mouse monoclonal antibody immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY FGF21.
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FGF21 Mouse anti-Human Monoclonal (OTI2E2) Antibody
Human
Flo, IF, WB
Unconjugated
100 µl/$434
FGF21 Antibody - HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY FGF21 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-FGF21.
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FGF21 Mouse anti-Human Monoclonal (OTI1B4) Antibody
Human
Flo, WB
Unconjugated
100 µl/$434
FGF21 Antibody - HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY FGF21 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-FGF21.
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FGF21 Mouse anti-Human Monoclonal (OTI3E5) Antibody
Human
Flo, WB
Unconjugated
100 µl/$434
FGF21 Antibody - HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY FGF21 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-FGF21.
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FGF21 Mouse anti-Human Monoclonal (OTI9A7) Antibody
Human
Flo, WB
Unconjugated
100 µl/$434
FGF21 Antibody - IHC of paraffin-embedded Human colon tissue using anti-FGF21 mouse monoclonal antibody.
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FGF21 Mouse anti-Human Monoclonal (OTI1H4) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
FGF21 Antibody - IHC of paraffin-embedded Human colon tissue using anti-FGF21 mouse monoclonal antibody.
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FGF21 Mouse anti-Human Monoclonal (Carrier-free) (OTI1H4) Antibody
Human
Flo, IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
FGF21 Antibody - IHC of paraffin-embedded Human Kidney tissue using anti-FGF21 mouse monoclonal antibody.
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FGF21 Mouse anti-Human Monoclonal (aa29-209) (Carrier-free) (OTI9E5) Antibody
Human
Flo, IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
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FGF21 Rabbit anti-Human Polyclonal (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
50 µg/$582
FGF21 Antibody - Western blot of recombinant FGF21.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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FGF21 Rabbit anti-Mouse Polyclonal (aa29-209) Antibody
Mouse
WB
Unconjugated
100 µl/$314; 200 µl/$359; 500 µl/$507; 1 ml/$581; 2 ml/$798; 5 ml/$1,296
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).