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FGF2 / Basic FGF
fibroblast growth factor 2 (basic)
FGF2 / Basic FGF is a member of the fibroblast growth factor (FGF) family. FGF family members bind heparin and possess broad mitogenic and angiogenic activities. This protein has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for this gene contains multiple polyadenylation sites, and is alternatively translated from non-AUG (CUG) and AUG initiation codons, resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF.
| Gene Name: | fibroblast growth factor 2 (basic) |
| Family/Subfamily: | HBGF , not assigned-HBGF |
| Synonyms: | FGF2, Basic fibroblast growth factor, FGFB, Fibroblast growth factor 2, FGF-2, Prostatropin, BFGF, HBGF-2 |
| Target Sequences: | NM_002006 NP_001997.5 P09038 |
Publications (1)
1
A phase Ib study of GSK3052230, an FGF ligand trap in combination with pemetrexed and cisplatin in patients with malignant pleural mesothelioma10<sup> Washington University School of Medicine, St. Louis, MO, USA12<sup> Memorial Sloan Kettering Cancer Center, New York, NY, USA14<sup> GlaxoSmithKline, Inc., 1250 South Collegeville Road, Collegeville, PA, USA16<sup> Utrecht University, Utrecht, The Netherlands18<sup> Phase I Trials Unit, Medical Oncology Department, Hospital Universitario Virgen de. Emilie M J van Brummelen, Evgeny Levchenko, Manuel Dómine, Dean A Fennell, Hedy L Kindler, Santiago Viteri, Shirish Gadgeel, Pilar Garrido López, Vladimir Kostorov, Daniel Morgensztern, Sergey Orlov, Marjorie G Zauderer, Johan F Vansteenkiste, Katherine Baker-Neblett, James Vasquez, Xiaowei Wang, David I Bellovin, Jan H M Schellens, Li Yan, Ionel Mitrica, M Phillip DeYoung, José Trigo. Investigational new drugs. 2020 Apr;;38:457-467. [Full Text Article]
[PubMed:31065954]
[PMC:PMC6898757]
Related Antibodies: LS-B10042.
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Products
Proteins
(59)
Type
Over-Expression Lysate
(2)
Recombinant
(56)
Target
FGF2 / Basic FGF
(59)
Format
Animal-free
(3)
Publications
No
(59)
Tag
6His-SUMO, N-terminus
(1)
GST, N-terminus
(1)
His
(4)
His, N-Terminal
(4)
His, N-terminus
(1)
His,N-terminus
(1)
His-T7
(1)
Myc-DDK (Flag)
(3)
Species
Bovine
(1)
Cow
(1)
Human
(34)
Mouse
(12)
Pig
(1)
Rabbit
(1)
Rat
(7)
Source
293T Cells
(1)
E. coli
(54)
HEK 293 Cells
(2)
Wheat Germ Extract
(1)
Purification
Purified
(14)
Low Endotoxin Level
Low endotoxin level
(43)
Biologically Active
Biologically active
(25)
Animal-free
Animal-free
(3)
E. coli
His, N-Terminal
17 kDa
10 µg/$265; 100 µg/$365; 50 µg/$315
E. coli
His
16.2 kDa
10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119
E. coli
None
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
16.3 kDa
50 µg/$342; 10 µg/$259; 1 mg/$834; 500 µg/$675
E. coli
None
Biologically active
Less than 0.2 EU/µg protein (determined by LAL method).
16.4 kDa (SDS-PAGE)
50 µg/$296; 10 µg/$253; 1 mg/$990
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
17.2 kDa
10 µg/$268; 50 µg/$352
E. coli
None
Biologically active
Less than 0.01 ng/µg of protein (Less than 0.1 EU/µg).
10 µg/$282; 50 µg/$369
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
16.4 kDa
10 µg/$268; 50 µg/$352
E. coli
None
Biologically active
Less than 0.01 ng/µg of protein (Less than 0.1 EU/µg).
10 µg/$282; 50 µg/$370
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
16.3 kDa
10 µg/$268; 50 µg/$349
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
16.3 kDa
10 µg/$268; 50 µg/$349
E. coli
None
Biologically active
Less than 0.01 ng/µg of protein (Less than 0.1 EU/µg).
10 µg/$282; 50 µg/$370
E. coli
None
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
250 µg/$739; 50 µg/$361
E. coli
His, N-Terminal
16.4 kDa
10 µg/$259; 50 µg/$331; 100 µg/$482; 200 µg/$602; 1 mg/$1,553; 500 µg/$1,156; 5 mg/$2,481; 2 mg/$1,723
None
Biologically active
17.2 kD
50 µg/$484
E. coli
None
Less than 1.0 EU/µg protein (determined by LAL method).
17.15kD
10 µg/$248; 50 µg/$313; 500 µg/$743; 1 mg/$1,048
E. coli
None
Less than 1.0 EU/µg protein (determined by LAL method).
16.4kD
10 µg/$248; 50 µg/$313; 500 µg/$530; 1 mg/$748
E. coli
None
Less than 1.0 EU/µg protein (determined by LAL method).
17.2kD
10 µg/$288; 50 µg/$442; 500 µg/$1,585; 1 mg/$2,157
E. coli
None
Less than 1.0 EU/µg protein (determined by LAL method).
17.3kD
10 µg/$248; 50 µg/$310; 500 µg/$523; 1 mg/$633
E. coli
None
Less than 1.0 EU/µg protein (determined by LAL method).
16.2kD
10 µg/$288; 50 µg/$442; 500 µg/$1,585; 1 mg/$2,157
HEK 293 Cells
Myc-DDK (Flag)
30.6 kDa
20 µg/$1,107
Wheat Germ Extract
GST, N-terminus
2 µg/$439
E. coli
None
Less than 1.0 EU/µg protein (determined by LAL method).
17.2kD
10 µg/$262; 50 µg/$321; 500 µg/$802; 1 mg/$1,113
E. coli
None
Less than 1.0 EU/µg protein (determined by LAL method).
17.2kD
10 µg/$262; 50 µg/$321; 500 µg/$802; 1 mg/$1,113
HEK 293 Cells
Myc-DDK (Flag)
30.6 kDa
100 µg/$494
293T Cells
Myc-DDK (Flag)
30.6 kDa
20 µg/$150
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