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Tyrosine-protein kinase that acts downstream of cell surface receptors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, cell attachment and cell spreading. Plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Acts down-stream of the activated FCER1 receptor and the mast/stem cell growth factor receptor KIT. Plays a role in the regulation of mast cell degranulation. Plays a role in the regulation of cell differentiation and promotes neurite outgrowth in response to NGF signaling. Plays a role in cell scattering and cell migration in response to HGF-induced activation of EZR. Phosphorylates BCR and down-regulates BCR kinase activity. Phosphorylates HCLS1/HS1, PECAM1, STAT3 and TRIM28.
Gene Name: | feline sarcoma oncogene |
Family/Subfamily: | Protein Kinase , Fes (Fps) |
Synonyms: | FES, c-fes, FPS, Feline sarcoma oncogene, Proto-oncogene c-Fps, v-fps, p93c-fes, Proto-oncogene c-Fes, v-fes, v-fes feline sarcoma viral |
Target Sequences: | NM_002005 NP_001996.1 P07332 |
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