FEN1

flap structure-specific endonuclease 1

Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.

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Products

Proteins (8)

Type

Over-Expression Lysate (2)

Recombinant (6)

Target

FEN1 (8)

Publications

No (8)

Tag

GST (1)

GST, N-terminus (1)

Myc-DDK (Flag) (3)

Species

Human (7)

Source

293T Cells (1)

E. coli (3)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (3)

Low Endotoxin Level

Low endotoxin level (2)

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Human FEN1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G75948

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

42.4 kDa

Price:

20 µg/$150

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Human FEN1 Protein (Recombinant GST, N-terminus) (aa1-110) - LS-G58549

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human FEN1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G65642

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

42.4 kDa

Price:

20 µg/$1,107

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Human FEN1 Protein (Recombinant GST) (Full Length) - LS-G28458

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

67.43 kDa

Price:

2 µg/$439

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FEN1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G100213

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

42.4 kDa

Price:

100 µg/$494

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Human FEN1 Protein (Recombinant) (Met1-Lys380) - LS-G139585

Source:

E. coli

Tag:

None

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

42.6 kDa

Price:

10 µg/$376; 50 µg/$526

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Human FEN1 Protein (Recombinant) - LS-G664

Source:

E. coli

Tag:

None

Price:

100 µg/$411; 500 µg/$985; 20 µg/$276

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Human FEN1 Protein (Recombinant) (Met1-Lys380) - LS-G38676

Source:

E. coli

Tag:

None

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

42.59kD

Price:

10 µg/$288; 50 µg/$442; 500 µg/$1,585; 1 mg/$2,157

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