Corporate Headquarters
Vector Laboratories, Inc.
6737 Mowry Ave
Newark, CA 94560
United States
FDPS is an enzyme that catalyzes the production of geranyl pyrophosphate and farnesyl pyrophosphate from isopentenyl pyrophosphate and dimethylallyl pyrophosphate. The resulting product, farnesyl pyrophosphate, is a key intermediate in cholesterol and sterol biosynthesis, a substrate for protein farnesylation and geranylgeranylation, and a ligand or agonist for certain hormone receptors and growth receptors. Drugs that inhibit this enzyme prevent the post-translational modifications of small GTPases and have been used to treat diseases related to bone resorption. Multiple pseudogenes have been found on chromosomes 1, 7, 14, 15, 21 and X. Multiple transcript variants encoding different isoforms have been found for this gene.
Gene Name: | farnesyl diphosphate synthase |
Synonyms: | FDPS, Dimethylallyltranstransferase, Farnesyl diphosphate synthase, FPP synthetase, FPS, KIAA1293, FPPS, Geranyltranstransferase, FPP synthase |
Target Sequences: | NM_002004 NP_001995.1 P14324 |
If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.