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FDFT1 / Squalene Synthase encodes a membrane-associated enzyme located at a branch point in the mevalonate pathway. The encoded protein is the first specific enzyme in cholesterol biosynthesis, catalyzing the dimerization of two molecules of farnesyl diphosphate in a two-step reaction to form squalene.
Gene Name: | farnesyl-diphosphate farnesyltransferase 1 |
Synonyms: | FDFT1, DGPT, ERG9, SS, Squalene synthetase, SQS, FPP:FPP farnesyltransferase, Squalene synthase |
Target Sequences: | NM_004462 NP_004453.3 P37268 |
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