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Binds to the Fc region of immunoglobulins epsilon. High affinity receptor. Responsible for initiating the allergic response. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators (such as histamine) responsible for the manifestations of allergy. The same receptor also induces the secretion of important lymphokines.
Gene Name: | Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide |
Family/Subfamily: | Immunoglobulin , not assigned-Immunoglobulin |
Synonyms: | FCER1A, Alpha polypeptide, FCE1A, FcERI, Fc Epsilon RI, Fc epsilon RI alpha-chain, Fc-epsilon RI-alpha, IgE Fc receptor subunit alpha |
Target Sequences: | NM_002001 NP_001992.1 P12319 |
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