FBXW7 / FBW7

F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase

FBXW7 / FBW7 is a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene was previously referred to as FBX30, and belongs to the Fbws class; in addition to an F-box, this protein contains 7 tandem WD40 repeats. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in this gene are detected in ovarian and breast cancer cell lines, implicating the gene's potential role in the pathogenesis of human cancers. Multiple transcript variants encoding different isoforms have been found for this gene.

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Products

Proteins (12)

Type

Over-Expression Lysate (6)

Recombinant (6)

Target

FBXW7 / FBW7 (12)

Publications

No (12)

Tag

6His, N-terminus (1)

GST (1)

GST, N-terminus (1)

His, N-Terminal (1)

His-T7 (2)

Myc-DDK (Flag) (6)

Species

Human (8)

Mouse (1)

Source

293T Cells (3)

E. coli (4)

HEK 293 Cells (3)

Wheat Germ Extract (2)

Purification

Purified (2)

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Human FBXW7 / FBW7 Protein (Recombinant 6His, N-terminus) (aa1-707) - LS-G56041

Source:

E. coli

Tag:

6His, N-terminus

Price:

100 µg/$1,128; 20 µg/$721

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Human FBXW7 / FBW7 Protein (Recombinant GST) (Full Length) - LS-G34273

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

88.7 kDa

Price:

2 µg/$439

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Human FBXW7 / FBW7 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G90925

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

70.1 kDa

Price:

20 µg/$215

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Human FBXW7 / FBW7 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G90926

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

79.5 kDa

Price:

20 µg/$215

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Human FBXW7 / FBW7 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G90923

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

65.9 kDa

Price:

20 µg/$215

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FBXW7 / FBW7 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G102138

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

79.5 kDa

Price:

100 µg/$710

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Human FBXW7 / FBW7 Protein (Recombinant GST, N-terminus) (aa599-707) - LS-G62683

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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FBXW7 / FBW7 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G111835

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

70.1 kDa

Price:

100 µg/$710

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FBXW7 / FBW7 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G121496

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

65.9 kDa

Price:

100 µg/$710

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Human FBXW7 / FBW7 Protein (Recombinant His, N-Terminal) - LS-G145130

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

65.9 kDa

Price:

50 µg/$419

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Human FBXW7 / FBW7 Protein (Recombinant His-T7) (aa279-515) - LS-G26043

Source:

E. coli

Tag:

His-T7

Molecular Weight:

30.8 kDa

Price:

10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204

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Mouse FBXW7 / FBW7 Protein (Recombinant His-T7) (aa312-545) - LS-G26044

Source:

E. coli

Tag:

His-T7

Molecular Weight:

29.5 kDa

Price:

10 µg/$287; 50 µg/$482; 100 µg/$770; 200 µg/$962; 1 mg/$2,094; 500 µg/$1,623; 5 mg/$3,361; 2 mg/$2,284

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