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FBXW12

F-box and WD repeat domain containing 12

Members of the F-box protein family, such as FBXW12, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603034), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).

Gene Name: F-box and WD repeat domain containing 12
Synonyms: FBXW12, FBXO35, F-box only protein 35, FBW12, FBXO12
Target Sequences: Q494Y9 Q6X9E4

Publications (1)

1
FBXW12, a novel F box protein-encoding gene, is deleted or methylated in some cases of epithelial ovarian cancer. De La Chesnaye E, Méndez JP, López-Romero R, De Los Angeles Romero-Tlalolini M, Vergara MD, Salcedo M, Ojeda SR. International journal of clinical and experimental pathology. 2015 8:10192-203. (WB; Human) [PubMed:26617728] [PMC:PMC4637543] Related Antibodies: LS-C166094.

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Proteins (3)
Over-Expression Lysate (2)
Recombinant (1)
FBXW12 (3)
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GST (1)
Myc-DDK (Flag) (2)
Human (2)
293T Cells (1)
HEK 293 Cells (1)
Wheat Germ Extract (1)
Purified (1)
FBXW12 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
52.9 kDa
20 µg/$215
FBXW12 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
52.9 kDa
100 µg/$710
FBXW12 Protein - 12.5% SDS-PAGE of human FBXW12 stained with Coomassie Blue
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Wheat Germ Extract
GST
77.2 kDa
10 µg/$479; 25 µg/$670
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If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).