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FBXO8 / FBX8 is a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. It contains a C-terminal amino acid sequence that bears a significant similarity with a portion of yeast Sec7p, a critical regulator of vesicular protein transport. This human protein may interact with ADP-ribosylation factor(s)(ARFs) and exhibit ARF-GEF (guanine nucleotide exchange factor) activity.
Gene Name: | F-box protein 8 |
Family/Subfamily: | F-Box |
Synonyms: | FBXO8, DC10, F-box protein Fbx8, FBX8, F-box only protein 8, F-box protein 8, FBS, F-box/SEC7 protein FBS |
Target Sequences: | NM_012180 NP_036312.2 Q9NRD0 |
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