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FBXO5 / EMI1
F-box protein 5
FBXO5 / EMI1 is a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. This protein is similar to xenopus early mitotic inhibitor-1 (Emi1), which is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase promoting complex. Alternatively spliced transcript variants encoding different isoforms have been identified.
| Gene Name: | F-box protein 5 |
| Family/Subfamily: | F-Box |
| Synonyms: | FBXO5, Early mitotic inhibitor 1, F-box protein 5, FBX5, F-box protein Fbx5, EMI1, F-box only protein 5 |
| Target Sequences: | NM_012177 NP_036309.1 Q9UKT4 |
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