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FBXO32 / Fbx32

F-box protein 32

FBXO32 / Fbx32 is a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and contains an F-box domain. This protein is highly expressed during muscle atrophy, whereas mice deficient in this gene were found to be resistant to atrophy. This protein is thus a potential drug target for the treatment of muscle atrophy. Alternative splicing results in multiple transcript variants encoding different isoforms.

Gene Name: F-box protein 32
Family/Subfamily: F-Box
Synonyms: FBXO32, Atrogin 1, ATROGIN1, F-box protein 32, F-box only protein 32, Fbx32, Muscle atrophy F-box protein, MAFBX, Atrogin-1
Target Sequences: NM_058229 NP_478136.1 Q969P5

Publications (1)

1
FBXO32 suppresses breast cancer tumorigenesis through targeting KLF4 to proteasomal degradation. Zhou H, Liu Y, Zhu R, Ding F, Wan Y, Li Y, Liu Z. Oncogene. 2017 June;36:3312-3321. (Human) [Full Text Article] [PubMed:28068319] [PMC:PMC5926769] Related Antibodies: LS-B9748.

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FBXO32 / Fbx32 (11)
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FBXO32 / Fbx32 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
39.063 - 2500 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$587
FBXO32 / Fbx32 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
FBXO32 / Fbx32 ELISA Kit
Select
Sandwich
96-Well Microplate
Mouse
39.06 - 2500 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
FBXO32 / Fbx32 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
FBXO32 / Fbx32 ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
1.563 - 100 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
FBXO32 / Fbx32 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Tissue Homogenates
1 Plate/$730
FBXO32 / Fbx32 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
7.8 - 500 pg/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$897
FBXO32 / Fbx32 ELISA Kit
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Custom
96-Well Strip Plate
Bovine
1 Plate/$669
FBXO32 / Fbx32 ELISA Kit
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Custom
96-Well Strip Plate
Human
1 Plate/$669
FBXO32 / Fbx32 ELISA Kit
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Custom
96-Well Strip Plate
Pig
1 Plate/$669
FBXO32 / Fbx32 ELISA Kit
Select
Custom
96-Well Strip Plate
Rat
1 Plate/$669
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).