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Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. The SCF(FBXO10) complex mediates ubiquitination and degradation of BCL2, an antiapoptotic protein, thereby playing a role in apoptosis by controlling the stability of BCL2.
Gene Name: | F-box protein 10 |
Family/Subfamily: | F-Box |
Synonyms: | FBXO10, F-box only protein 10, F-box protein 10, FBX10, F-box protein Fbx10, PRMT11 |
Target Sequences: | AF174598 AAF04519.1 Q9UK96 |
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