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FBXL19 is a member of the Skp1-Cullin-F-box family of E3 ubiquitin ligases. The encoded protein is reported to bind to the transmembrane receptor interleukin 1 receptor-like 1 and regulate its ubiquitination and degradation. This protein has been linked to the regulation of pulmonary inflammation and psoriasis. Alternative splicing results in multiple transcript variants.
Gene Name: | F-box and leucine-rich repeat protein 19 |
Synonyms: | FBXL19, F-box/LRR-repeat protein 19, JHDM1C, Fbl19 |
Target Sequences: | NM_001099784 NP_001093254.2 Q6PCT2 |
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