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Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the polyubiquitination and proteasomal degradation of CAMK1 leading to disruption of cyclin D1/CDK4 complex assembly which results in G1 cell cycle arrest in lung epithelia.
Gene Name: | F-box and leucine-rich repeat protein 12 |
Family/Subfamily: | F-Box |
Synonyms: | FBXL12, Fbl12, F-box protein FBL12, F-box/LRR-repeat protein 12 |
Target Sequences: | NM_017703 NP_060173.1 Q9NXK8 |
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