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FBLN5 / Fibulin 5

fibulin 5

FBLN5 / Fibulin 5 is a secreted, extracellular matrix protein containing an Arg-Gly-Asp (RGD) motif and calcium-binding EGF-like domains. It promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. It is prominently expressed in developing arteries but less so in adult vessels. However, its expression is reinduced in balloon-injured vessels and atherosclerotic lesions, notably in intimal vascular smooth muscle cells and endothelial cells. Therefore, the protein encoded by this gene may play a role in vascular development and remodeling. Defects in this gene are a cause of autosomal dominant cutis laxa, autosomal recessive cutis laxa type I (CL type I), and age-related macular degeneration type 3 (ARMD3).

Gene Name: fibulin 5
Synonyms: FBLN5, ARCL1A, ARMD3, FIBL-5, ADCL2, EVEC, Fibulin 5, Urine p50 protein, DANCE, Fibulin-5, UP50
Target Sequences: NM_006329 NP_006320.2 Q9UBX5

Publications (3)

1
Fibulin 5, a human Wharton's jelly-derived mesenchymal stem cells-secreted paracrine factor, attenuates peripheral nervous system myelination defects through the Integrin-RAC1 signaling axis. So Yeon Won, Soojin Kwon, Hui Su Jeong, Ki Wha Chung, Byung-Ok Choi, Jong Wook Chang, Ji Eun Lee. Stem cells (Dayton, Ohio). 2020 October; [Full Text Article] [PubMed:33107705] [PMC:PMC7756588]
2
A Non-Invasive Determination of LOXL1 and Fibulin-5 Levels in the Vaginal Secretions of Women with and Without Pelvic Organ Prolapse. Bobby Garcia, Afiba Arthur, Bansari Patel, Jenny Chang, Dongbao Chen, Felicia Lane. Journal of medical research and surgery. 2021 Apr;;2:10.52916/jmrs214042. [Full Text Article] [PubMed:34318305] [PMC:PMC8312730]
3
TAZ-CAMTA1 and YAP-TFE3 alter the TAZ/YAP transcriptome by recruiting the ATAC histone acetyltransferase complex. Nicole Merritt , Keith Garcia , Dushyandi Rajendran, Zhen-Yuan Lin, Xiaomeng Zhang, Katrina A Mitchell, Nicholas Borcherding, Colleen Fullenkamp, Michael S Chimenti, Anne-Claude Gingras, Kieran F Harvey, Munir R Tanas. eLife. 2021 April;10:e62857. [Full Text Article] [PubMed:33913810] [PMC:PMC8143797] Related Antibodies: LS-B14518.

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Proteins (8)
Over-Expression Lysate (2)
Recombinant (6)
FBLN5 / Fibulin 5 (8)
No (8)
GST (1)
His (3)
His-T7 (1)
Myc-DDK (Flag) (3)
Human (4)
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Rat (1)
293T Cells (1)
E. coli (4)
HEK 293 Cells (2)
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Purified (1)
FBLN5 / Fibulin 5 Protein - 12.5% SDS-PAGE of human FBLN5 stained with Coomassie Blue
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Wheat Germ Extract
GST
76.6 kDa
10 µg/$479; 25 µg/$670
FBLN5 / Fibulin 5 Protein - Recombinant Fibulin 5 By SDS-PAGE
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E. coli
His
15.5 kDa
10 µg/$283; 50 µg/$452; 100 µg/$725; 200 µg/$905; 1 mg/$2,020; 500 µg/$1,558; 5 mg/$3,165; 2 mg/$2,209
FBLN5 / Fibulin 5 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
50.18 kDa
20 µg/$150
FBLN5 / Fibulin 5 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
50.18 kDa
100 µg/$494
FBLN5 / Fibulin 5 Protein - Purified recombinant protein FBLN5 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
47.8 kDa
20 µg/$1,107
FBLN5 / Fibulin 5 Protein - Recombinant Fibulin 5 By SDS-PAGE
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E. coli
His-T7
15.7 kDa
10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176
FBLN5 / Fibulin 5 Protein - Recombinant Fibulin 5 By SDS-PAGE
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E. coli
His
21.3 kDa
10 µg/$287; 50 µg/$482; 100 µg/$770; 200 µg/$962; 1 mg/$2,094; 500 µg/$1,623; 5 mg/$3,361; 2 mg/$2,284
FBLN5 / Fibulin 5 Protein - Recombinant Fibulin 5 By SDS-PAGE
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E. coli
His
9.7 kDa
10 µg/$283; 50 µg/$452; 100 µg/$725; 200 µg/$905; 1 mg/$2,020; 500 µg/$1,558; 5 mg/$3,165; 2 mg/$2,209
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).