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FBL8 / FBXL8 is a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class. It shares 78% sequence identity with the mouse protein.
Gene Name: | F-box And Leucine-rich Repeat Protein 8 |
Family/Subfamily: | F-Box |
Synonyms: | FBXL8, F-box protein FBL8, F-box/LRR-repeat protein 8, FBL8 |
Target Sequences: | NM_018378 NP_060848.2 Q96CD0 |
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