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FBL / FIB / Fibrillarin

fibrillarin

S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins. Involved in pre-rRNA processing by catalyzing the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA. Also acts as a protein methyltransferase by mediating methylation of 'Gln-105' of histone H2A (H2AQ104me), a modification that impairs binding of the FACT complex and is specifically present at 35S ribosomal DNA locus (PubMed:24352239).

Gene Name: fibrillarin
Synonyms: FBL, FLRN, FBRL, FIB1, Fibrillarin, RNU3IP1, FIB
Target Sequences: NM_001436 NP_001427.2 P22087

Publications (3)

1
Pinpointing the expression of piRNAs and function of the PIWI protein subfamily during spermatogenesis in the mouse. Beyret E, Lin H. Developmental biology. 2011 355:215-26. (IHC-Fr; Mouse) [PubMed:21539824] [PMC:PMC3443393]
2
The chemotherapeutic agent CX-5461 irreversibly blocks RNA polymerase I initiation and promoter release to cause nucleolar disruption, DNA damage and cell inviability. Jean-Clément Mars, Michel G Tremblay, Mélissa Valere, Dany S Sibai, Marianne Sabourin-Felix, Frédéric Lessard, Tom Moss. NAR cancer. 2020 December;2:zcaa032. [Full Text Article] [PubMed:33196044] [PMC:PMC7646227] Related Antibodies: LS-C155047.
3
Ribosomal DNA promoter recognition is determined in vivo by cooperation between UBTF1 and SL1 and is compromised in the UBTF-E210K neuroregression syndrome. Michel G Tremblay, Dany S Sibai, Melissa Valère, Jean-Clément Mars, Frédéric Lessard, Roderick T Hori, Mohammad Moshahid Khan, Victor Y Stefanovsky, Mark S LeDoux, Tom Moss. PLoS genetics. 2022 February;18:e1009644. [Full Text Article] [PubMed:35139074] [PMC:PMC8863233] Related Antibodies: LS-C155047.

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Products
ELISA Kits (8)
Sandwich (8)
FBL / FIB / Fibrillarin (8)
Human (2)
Mouse (1)
Chicken (1)
Monkey (1)
Porcine (1)
Rabbit (1)
Sheep (1)
96-Well Microplate (1)
96-Well Strip Plate (7)
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Plasma (3)
Serum (3)
Tissue Homogenates (1)
FBL / FIB / Fibrillarin ELISA Kit
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Sandwich
96-Well Microplate
Human
1.563 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
FBL / FIB / Fibrillarin ELISA Kit
Select
Sandwich
96-Well Strip Plate
Monkey
1.563 - 100 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
FBL / FIB / Fibrillarin ELISA Kit
Select
Sandwich
96-Well Strip Plate
Chicken
1.563 - 100 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
FBL / FIB / Fibrillarin ELISA Kit
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Sandwich
96-Well Strip Plate
Porcine
1.563 - 100 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
FBL / FIB / Fibrillarin ELISA Kit
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Sandwich
96-Well Strip Plate
Rabbit
0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
FBL / FIB / Fibrillarin ELISA Kit
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Sandwich
96-Well Strip Plate
Sheep
0.781 - 50 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$691
FBL / FIB / Fibrillarin ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
1.563 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
FBL / FIB / Fibrillarin ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).