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FAT10 / UBD

ubiquitin D

Ubiquitin-like protein modifier which can be covalently attached to target protein and subsequently leads to their degradation by the 26S proteasome, in a NUB1L-dependent manner. Probably functions as a survival factor. Conjugation ability activated by UBA6. Promotes the expression of the proteasome subunit beta type-9 (PSMB9/LMP2). Regulates TNF-alpha-induced and LPS-mediated activation of the central mediator of innate immunity NF-kappa-B by promoting TNF-alpha-mediated proteasomal degradation of ubiquitinated-I-kappa-B-alpha. Required for TNF-alpha-induced p65 nuclear translocation in renal tubular epithelial cells (RTECs). May be involved in dendritic cell (DC) maturation, the process by which immature dendritic cells differentiate into fully competent antigen-presenting cells that initiate T-cell responses. Mediates mitotic non-disjunction and chromosome instability, in long-term in vitro culture and cancers, by abbreviating mitotic phase and impairing the kinetochore localization of MAD2L1 during the prometaphase stage of the cell cycle. May be involved in the formation of aggresomes when proteasome is saturated or impaired. Mediates apoptosis in a caspase-dependent manner, especially in renal epithelium and tubular cells during renal diseases such as polycystic kidney disease and Human immunodeficiency virus (HIV)-associated nephropathy (HIVAN).

Gene Name: ubiquitin D
Synonyms: UBD, FAT10, Diubiquitin, Ubiquitin D, Ubiquitin-like protein FAT10, UBD-3
Target Sequences: NM_006398 NP_006389.2 O15205

Publications (2)

1
Homology-independent multiallelic disruption via CRISPR/Cas9-based knock-in yields distinct functional outcomes in human cells. Zhang C, He X, Kwok YK, Wang F, Xue J, Zhao H, Suen KW, Wang CC, Ren J, Chen GG, Lai PBS, Li J, Xia Y, Chan AM, Chan WY, Feng B. BMC biology. 2018 December;16:151. [Full Text Article] [PubMed:30593266] [PMC:PMC6310992] Related Antibodies: LS-C341638.
2
Guanylate-binding protein 5 is a marker of interferon-?-induced classically activated macrophages. Fujiwara Y, Hizukuri Y, Yamashiro K, Makita N, Ohnishi K, Takeya M, Komohara Y, Hayashi Y. Clinical and Translational Immunology. 2016 November;5:e111. [Full Text Article] [PubMed:27990286] [PMC:PMC5133363]

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FAT10 / UBD (12)
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FAT10 / UBD ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$669
FAT10 / UBD ELISA Kit
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Sandwich
96-Well Strip Plate
Human
3.125 - 200 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
FAT10 / UBD ELISA Kit
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Custom
96-Well Strip Plate
Human
Colorimetric - 450nm (TMB)
1 Plate/$669
FAT10 / UBD ELISA Kit
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Custom
96-Well Strip Plate
Rat
Colorimetric - 450nm (TMB)
1 Plate/$669
FAT10 / UBD ELISA Kit
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Sandwich
96-Well Strip Plate
Human
3.13 - 200 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$798
FAT10 / UBD ELISA Kit
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Sandwich
96-Well Microplate
Human
3.125 - 200 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
FAT10 / UBD ELISA Kit
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Sandwich
96-Well Strip Plate
Monkey
3.125 - 200 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
FAT10 / UBD ELISA Kit
Select
Sandwich
96-Well Strip Plate
Chicken
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
FAT10 / UBD ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rabbit
125 - 8000 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
FAT10 / UBD ELISA Kit
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Sandwich
96-Well Strip Plate
Porcine
3.125 - 200 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
FAT10 / UBD ELISA Kit
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Sandwich
96-Well Strip Plate
Sheep
1.563 - 100 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$691
FAT10 / UBD ELISA Kit
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Sandwich CLIA
12 x 8-Well Microstrips
Human
0.781 - 50 ng/ml
Chemiluminescent
Plasma, Serum
1 Plate/$656
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).