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FAT10 / UBD

ubiquitin D

Ubiquitin-like protein modifier which can be covalently attached to target protein and subsequently leads to their degradation by the 26S proteasome, in a NUB1L-dependent manner. Probably functions as a survival factor. Conjugation ability activated by UBA6. Promotes the expression of the proteasome subunit beta type-9 (PSMB9/LMP2). Regulates TNF-alpha-induced and LPS-mediated activation of the central mediator of innate immunity NF-kappa-B by promoting TNF-alpha-mediated proteasomal degradation of ubiquitinated-I-kappa-B-alpha. Required for TNF-alpha-induced p65 nuclear translocation in renal tubular epithelial cells (RTECs). May be involved in dendritic cell (DC) maturation, the process by which immature dendritic cells differentiate into fully competent antigen-presenting cells that initiate T-cell responses. Mediates mitotic non-disjunction and chromosome instability, in long-term in vitro culture and cancers, by abbreviating mitotic phase and impairing the kinetochore localization of MAD2L1 during the prometaphase stage of the cell cycle. May be involved in the formation of aggresomes when proteasome is saturated or impaired. Mediates apoptosis in a caspase-dependent manner, especially in renal epithelium and tubular cells during renal diseases such as polycystic kidney disease and Human immunodeficiency virus (HIV)-associated nephropathy (HIVAN).

Gene Name: ubiquitin D
Synonyms: UBD, FAT10, Diubiquitin, Ubiquitin D, Ubiquitin-like protein FAT10, UBD-3
Target Sequences: NM_006398 NP_006389.2 O15205

Publications (2)

1
Homology-independent multiallelic disruption via CRISPR/Cas9-based knock-in yields distinct functional outcomes in human cells. Zhang C, He X, Kwok YK, Wang F, Xue J, Zhao H, Suen KW, Wang CC, Ren J, Chen GG, Lai PBS, Li J, Xia Y, Chan AM, Chan WY, Feng B. BMC biology. 2018 December;16:151. [Full Text Article] [PubMed:30593266] [PMC:PMC6310992] Related Antibodies: LS-C341638.
2
Guanylate-binding protein 5 is a marker of interferon-?-induced classically activated macrophages. Fujiwara Y, Hizukuri Y, Yamashiro K, Makita N, Ohnishi K, Takeya M, Komohara Y, Hayashi Y. Clinical and Translational Immunology. 2016 November;5:e111. [Full Text Article] [PubMed:27990286] [PMC:PMC5133363]

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FAT10 / UBD (64)
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FAT10 / UBD Antibody - FAT10 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human stomach carcinoma followed by peroxidase-conjugated secondary antibody and DAB staining.
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FAT10 / UBD Rabbit anti-Human Polyclonal (aa120-153) Antibody
Mouse, Human
IF, IHC, IHC-P, WB
Unconjugated
400 µl/$393
FAT10 / UBD Antibody - Western blot of recombinant FAT10 / UBD.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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FAT10 / UBD Rabbit anti-Human Polyclonal (aa1-165) Antibody
Mouse, Human
WB
Unconjugated
100 µl/$303; 200 µl/$343; 500 µl/$476; 1 ml/$543; 2 ml/$715; 5 ml/$1,182
FAT10 / UBD Antibody - Immunohistochemistry of paraffin-embedded rat liver tissue.
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FAT10 / UBD Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
FAT10 / UBD ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$669
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FAT10 / UBD Rabbit anti-Human Polyclonal Antibody
Human
IHC, WB
Unconjugated
50 µl/$356; 100 µl/$461
FAT10 / UBD Antibody - Western blot analysis of FAT10 expression in K562 (A); HEK293T (B) whole cell lysates.
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FAT10 / UBD Rabbit anti-Human Polyclonal (Internal) Antibody
Human
WB
Unconjugated
100 µl/$321
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FAT10 / UBD Rabbit anti-Human Polyclonal (aa120-153) Antibody
Mouse, Human
ELISA, IF, IHC, WB
Unconjugated
200 µl/$734
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FAT10 / UBD Rabbit anti-Mouse Polyclonal (aa120-153) (Biotin) Antibody
Mouse
ELISA, ICC, IF, IHC, WB
Biotin Conjugated
200 µl/$952
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FAT10 / UBD Rabbit anti-Mouse Polyclonal (aa120-153) (FITC) Antibody
Mouse
ELISA, ICC, IF, IHC, WB
FITC Conjugated
200 µl/$952
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FAT10 / UBD Rabbit anti-Mouse Polyclonal (aa120-153) (APC) Antibody
Mouse
ELISA, ICC, IF, IHC, WB
APC Conjugated
200 µl/$952
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FAT10 / UBD Rabbit anti-Mouse Polyclonal (aa120-153) (Azide-free) (HRP) Antibody
Mouse
ELISA, ICC, IF, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
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FAT10 / UBD Rabbit anti-Mouse Polyclonal (aa120-153) (PE) Antibody
Mouse
ELISA, ICC, IF, IHC, WB
PE Conjugated
200 µl/$952
FAT10 / UBD Antibody - Staining HeLa cells by IF/ICC. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 min at 25°C. The primary antibody was diluted at 1:200 and incubated with the sample for 1 hour at 37°C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) antibody, diluted at 1/600, was used as secondary antibody.
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FAT10 / UBD Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
FAT10 / UBD Antibody - Immunohistochemistry of UBD in human testis tissue with UBD antibody at 5 µg/mL.
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FAT10 / UBD Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
0.1 mg/$460
FAT10 / UBD Antibody - Western blot of recombinant FAT10 / UBD.
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FAT10 / UBD Rabbit anti-Rat Polyclonal (aa1-155) (PE) Antibody
Rat
WB
PE Conjugated
100 µl/$412; 200 µl/$499; 500 µl/$869; 1 ml/$1,030; 2 ml/$1,345; 5 ml/$2,521
FAT10 / UBD Antibody - Immunohistochemistry of paraffin-embedded rat liver using UBD antibody at dilution of 1:200 (40x lens).
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FAT10 / UBD Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC
Unconjugated
20 µl/$275; 100 µl/$389
FAT10 / UBD Antibody - Immunofluorescence staining of UBD in HeLa cells. Cells were fixed with 4% PFA, permeabilzed with 0.1% Triton X-100 in PBS, blocked with 10% serum, and incubated with rabbit anti-human UBD polyclonal antibody (dilution ratio 1:1000) at 4°C overnight. Then cells were stained with the Alexa Fluor 488-conjugated Goat Anti-rabbit IgG secondary antibody (green). Positive staining was localized to Nucleus.
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FAT10 / UBD Rabbit anti-Human Polyclonal (Preservative Free) Antibody
Human
ICC, IF, WB
Unconjugated, Preservative Free
100 µl/$412
FAT10 / UBD Antibody - Anti-Diubiquitin antibody, IHC(P): Human Tonsil Tissue
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FAT10 / UBD Rabbit anti-Human Polyclonal (aa27-40) Antibody
Human
IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
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FAT10 / UBD Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
FAT10 / UBD Antibody - Immunohistochemistry of paraffin-embedded Human tonsil tissue  using UBD Polyclonal Antibody at dilution of 1:50(×200)
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FAT10 / UBD Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
FAT10 / UBD Antibody - Immunohistochemistry of paraffin-embedded Human tonsil tissue  using UBD Polyclonal Antibody at dilution of 1:50(×200)
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FAT10 / UBD Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
FAT10 / UBD Antibody - Western Blot (WB) analysis of K562 using FAT10 antibody.
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FAT10 / UBD Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
FAT10 / UBD Antibody - HepG2 cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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FAT10 / UBD Rabbit anti-Human Polyclonal (aa38-87) Antibody
Human
WB
Unconjugated
100 µl/$424
FAT10 / UBD Antibody - Immunohistochemistry of paraffin-embedded human kidney tissue using UBD Antibody at dilution of 1:100
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FAT10 / UBD Rabbit anti-Human Polyclonal (aa1-165) Antibody
Human
ELISA
Unconjugated
50 µg/$294; 100 µg/$360
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FAT10 / UBD Rabbit anti-Human Polyclonal (aa1-165) (Biotin) Antibody
Human
ELISA
Biotin Conjugated
50 µg/$294; 100 µg/$360
Viewing 1-25 of 64 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).