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FASN / Fatty Acid Synthase

fatty acid synthase

The enzyme encoded by this gene is a multifunctional protein. Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha.

Gene Name: fatty acid synthase
Synonyms: FASN, Fatty acid synthase, OA-519, SDR27X1
Target Sequences: NM_004104 NP_004095.4 P49327

Publications (8)

1
FAS inhibitor cerulenin reduces food intake and melanocortin receptor gene expression without modulating the other (an)orexigenic neuropeptides in chickens. Dridi S, Ververken C, Hillgartner FB, Arckens L, Lutgarde A, Van der Gucht E, Cnops L, Decuypere E, Buyse J. American journal of physiology. Regulatory, integrative and comparative physiology. 2006 291:R138-47. [PubMed:16455759]
2
Androgen deprivation increases p300 expression in prostate cancer cells. Heemers HV, Sebo TJ, Debes JD, Regan KM, Raclaw KA, Murphy LM, Hobisch A, Culig Z, Tindall DJ. Cancer research. 2007 67:3422-30. [PubMed:17409453]
3
1-11C-acetate as a PET radiopharmaceutical for imaging fatty acid synthase expression in prostate cancer. Vvere AL, Kridel SJ, Wheeler FB, Lewis JS. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2008 49:327-34. [PubMed:18199615]
4
Mechanisms of antidiabetogenic and body weight-lowering effects of estrogen in high-fat diet-fed mice. Bryzgalova G, Lundholm L, Portwood N, Gustafsson JA, Khan A, Efendic S, Dahlman-Wright K. American journal of physiology. Endocrinology and metabolism. 2008 295:E904-12. [PubMed:18697913] [PMC:PMC2575902]
5
A selective estrogen receptor agonist ameliorates hepatic steatosis in the male aromatase knockout mouse. Chow JD, Jones ME, Prelle K, Simpson ER, Boon WC. The Journal of endocrinology. 2011 210:323-34. (WB; Mouse) [PubMed:21705395]
6
Proteasome inhibitor treatment reduced fatty acid, triacylglycerol and cholesterol synthesis. Oliva J, French SW, Li J, Bardag-Gorce F. Experimental and molecular pathology. 2012 93:26-34. (WB; Rat) [PubMed:22445925]
7
Modulatory role of PYY in transport and metabolism of cholesterol in intestinal epithelial cells. Grenier E, Garofalo C, Delvin E, Levy E. PloS one. 2012 7:e40992. (WB; Human) [PubMed:22844422] [PMC:PMC3402548]
8
Oncogenic Integration of Nucleotide Metabolism via Fatty Acid Synthase in Non-Hodgkin Lymphoma10<sup> Department of Medicine, University of Rochester Medical Center, Rochester, NY, United States12<sup> Bioinformatics Core, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, United States14<sup> Harold Hamm Diabetes Center, The University of Oklahoma Health Sciences Center, Oklahoma, OK, United States16<sup> Department of Medicine, Duke Cancer Institute, Duke University Medical Center, Dur. Dashnamoorthy Ravi , Afshin Beheshti , Nasséra Abermil, Frederick Lansigan , William Kinlaw, Nirupa R Matthan, Maisarah Mokhtar, Frank C Passero Jr, Patrick Puliti , Kevin A David , Gregory G Dolnikowski, Xiaoyang Su , Ying Chen, Mahboubi Bijan, Rohan R Varshney, Baek Kim , Sandeep S Dave, Michael C Rudolph, Andrew M Evens. Frontiers in oncology. 2021 Oct;11:725137. [Full Text Article] [PubMed:34765544] [PMC:PMC8576537] Related Antibodies: LS-C104946.
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FASN / Fatty Acid Synthase (10)
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Human FASN / Fatty Acid Synthase Protein (Recombinant 6His, N-terminus) (aa2155-2495) - LS-G22591
E. coli
6His, N-terminus
41.8 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
FASN / Fatty Acid Synthase Protein - Recombinant Fatty Acid Synthase By SDS-PAGE
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Mouse FASN / Fatty Acid Synthase Protein (Recombinant His) (aa2257-2504) - LS-G14941
E. coli
His
28.7 kDa
10 µg/$279; 50 µg/$432; 100 µg/$690; 200 µg/$862; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148
FASN / Fatty Acid Synthase Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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Human FASN / Fatty Acid Synthase Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G75893
293T Cells
Myc-DDK (Flag)
273.2 kDa
20 µg/$215
FASN / Fatty Acid Synthase Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
Select
Human FASN / Fatty Acid Synthase Protein (Recombinant GST, N-terminus) (aa2378-2477) - LS-G58534
Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
FASN / Fatty Acid Synthase Protein - Purified recombinant protein FASN was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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Human FASN / Fatty Acid Synthase Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G65611
HEK 293 Cells
Myc-DDK (Flag)
273.2 kDa
20 µg/$1,107
FASN / Fatty Acid Synthase Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
FASN / Fatty Acid Synthase Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G116868
HEK 293 Cells
Myc-DDK (Flag)
273.2 kDa
100 µg/$710
FASN / Fatty Acid Synthase Protein - 12.5% SDS-PAGE of human FASN stained with Coomassie Blue
Select
Human FASN / Fatty Acid Synthase Protein (Recombinant GST) (Full Length) - LS-G28441
Wheat Germ Extract
GST
74.03 kDa
10 µg/$479; 25 µg/$670
FASN / Fatty Acid Synthase Protein - Recombinant Fatty Acid Synthase By SDS-PAGE
Select
Chicken FASN / Fatty Acid Synthase Protein (Recombinant His) (aa2263-2512) - LS-G14939
E. coli
His
29.1 kDa
10 µg/$289; 50 µg/$492; 100 µg/$785; 200 µg/$982; 1 mg/$2,119; 500 µg/$1,646; 5 mg/$3,431; 2 mg/$2,309
FASN / Fatty Acid Synthase Protein - Recombinant Fatty Acid Synthase By SDS-PAGE
Select
Human FASN / Fatty Acid Synthase Protein (Recombinant His-GST) (aa26-78) - LS-G14938
E. coli
His-GST
38.3 kDa
10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060
FASN / Fatty Acid Synthase Protein - Recombinant Fatty Acid Synthase By SDS-PAGE
Select
Rat FASN / Fatty Acid Synthase Protein (Recombinant His-T7) (aa2243-2505) - LS-G14942
E. coli
His-T7
32.3 kDa
10 µg/$278; 50 µg/$422; 100 µg/$677; 200 µg/$845; 1 mg/$1,938; 500 µg/$1,485; 5 mg/$2,955; 2 mg/$2,124
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