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FAM162A / C3orf28
family with sequence similarity 162, member A
Proposed to be involved in regulation of apoptosis; the exact mechanism may differ between cell types/tissues. May be involved in hypoxia-induced cell death of transformed cells implicating cytochrome C release and caspase activation (such as CASP9) and inducing mitochondrial permeability transition. May be involved in hypoxia-induced cell death of neuronal cells probably by promoting release of AIFM1 from mitochondria to cytoplasm and its translocation to the nucleus; however, the involvement of caspases has been reported conflictingly.
| Gene Name: | family with sequence similarity 162, member A |
| Synonyms: | FAM162A, E2-induced gene 5 protein, HGTD-P, Protein FAM162A, C3orf28, E2IG5 |
| Target Sequences: | NM_014367 NP_055182.3 Q96A26 |
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