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Guanine nucleotide exchange factor (GEF) for RAB14. Component of an endocytic recycling pathway that is required for the control of ADAM10 transport, shedding of N-cadherin/CDH2 by ADAM9 or ADAM10 and regulation of cell-cell junctions. Required for RAB14 recruitment to recycling endosomes.
Gene Name: | DENN/MADD domain containing 6A |
Synonyms: | DENND6A, AFI1A, FAM116A, DENN/MADD domain containing 6A |
Target Sequences: | Q8IWF6 Q8IWF6 |
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