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F9 / Factor IX

coagulation factor IX

F9 / Factor IX is a vitamin K-dependent coagulation factor IX that circulates in the blood as an inactive zymogen. This factor is converted to an active form by factor XIa, which excises the activation peptide and thus generates a heavy chain and a light chain held together by one or more disulfide bonds. The role of this activated factor IX in the blood coagulation cascade is to activate factor X to its active form through interactions with Ca+2 ions, membrane phospholipids, and factor VIII. Alterations of this gene, including point mutations, insertions and deletions, cause factor IX deficiency, which is a recessive X-linked disorder, also called hemophilia B or Christmas disease.

Gene Name: coagulation factor IX
Family/Subfamily: Protease , Serine S1
Synonyms: F9, Christmas Disease, Coagulation factor IX, Factor IX Deficiency, FIX, HEMB, F9 p22, Factor 9, Factor IX, Factor IX F9, FIX F9, Haemophilia B, THPH8, Christmas factor, Hemophilia B, PTC, Serine protease
Target Sequences: NM_000133 NP_000124.1 P00740

Publications (4)

1
Targeted introduction and effective expression of hFIX at the AAVS1 locus in mesenchymal stem cells. Li SJ, Luo Y, Zhang LM, Yang W, Zhang GG. Molecular medicine reports. 2017 March;15:1313-1318. [Full Text Article] [PubMed:28112377] [PMC:PMC5367337]
2
Preclinical development of plant-based oral immune modulatory therapy for haemophilia B. Aparajitha Srinivasan, Roland W Herzog, Imran Khan, Alexandra Sherman, Thais Bertolini, Tung Wynn, Henry Daniell. Plant biotechnology journal. 2021 Oct;;19:1952-1966. [Full Text Article] [PubMed:33949086] [PMC:PMC8486253]
3
A novel next-generation FVIIIa mimetic, Mim8, has a favorable safety profile and displays potent pharmacodynamic effects: Results from safety studies in cynomolgus monkeys. Brian Lauritzen, Mads Bjelke, Olle Björkdahl, Esther Bloem, Kevin Keane, Marianne Kjalke, Marie Rossen, Solvej Lund Lippert, Karin Nana Weldingh, Mikala Skydsgaard, Stine Kjellev. Journal of thrombosis and haemostasis : JTH. 2022 June;20:1312-1324. [Full Text Article] [PubMed:35191180] [PMC:PMC9314625] Related Antibodies: LS-B7226.
4
A lipoprotein receptor cluster IV mutant preferentially binds amyloid- beta and regulates its clearance from the mouse brain. Sagare AP, Bell RD, Srivastava A, Sengillo JD, Singh I, Nishida Y, Chow N, Zlokovic BV. The Journal of biological chemistry. 2013 May;288:15154-66. [Full Text Article] [PubMed:23580652] [PMC:PMC3663536] Related Antibodies: LS-C23381.
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Antibodies (118)
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F9 / Factor IX (159)
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F9 / Factor IX Antibody - Anti-F9 / Factor IX antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Select
F9 / Factor IX Goat anti-Human Polyclonal Antibody
Human
ELISA, IE, IHC, IHC-P
Unconjugated
250 µg/$485
Select
F9 / Factor IX Mouse anti-Human Monoclonal Antibody
Human
ELISA, IHC, RIA, WB
Unconjugated
100 µg/$518
Select
F9 / Factor IX Goat anti-Human Polyclonal (HRP) Antibody
Human
ELISA, IE
HRP Conjugated
100 µg/$611
Select
F9 / Factor IX Goat anti-Human Polyclonal (HRP) Antibody
Human
ELISA, IE
HRP Conjugated
200 µg/$611
F9 / Factor IX Antibody - Anti-F9 / Factor IX antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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F9 / Factor IX Mouse anti-Human Monoclonal (13F42-F6) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
0.25 mg/$575
F9 / Factor IX Antibody - Anti-F9 / Factor IX antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 2.5 ug/ml.
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F9 / Factor IX Sheep anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, Neut
Unconjugated
100 µg/$575
F9 / Factor IX Antibody - Anti-F9 / Factor IX antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Select
F9 / Factor IX Sheep anti-Human Polyclonal Antibody
Human
ELISA, IE, IHC, IHC-P
Unconjugated
0.5 mg/$460
F9 / Factor IX Antibody
Select
F9 / Factor IX Rabbit anti-Human Polyclonal (aa48-191) Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µl/$332
Select
F9 / Factor IX Mouse anti-Human Monoclonal (1C2) Antibody
Human
ELISA, WB
Unconjugated
100 µl/$824
Select
F9 / Factor IX Mouse anti-Human Monoclonal (CaFIX-1) Antibody
Human
ELISA, WB
Unconjugated
200 µg/$503
Select
F9 / Factor IX Sheep anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$335; 1 mg/$417; 10 mg/$2,196
Select
F9 / Factor IX Mouse anti-Human Monoclonal Antibody
Human
ELISA, WB
Unconjugated
100 µl/$824
F9 / Factor IX ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
1.56 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma
1 Plate/$782
F9 / Factor IX ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma
1 Plate/$764
F9 / Factor IX ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.1 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma
1 Plate/$629
F9 / Factor IX ELISA Kit
Select
Sandwich
96-Well Microplate
Mouse
0.16 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
F9 / Factor IX ELISA Kit
Select
Sandwich
96-Well Microplate
Human
1.25 - 80 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$528
F9 / Factor IX ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.781 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$587
F9 / Factor IX ELISA Kit
Select
Sandwich
12 x 8-Well Microstrips
Monkey
0.31 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$728
F9 / Factor IX Antibody - Immunohistochemistry of paraffin-embedded human liver tissue using F9 Antibody at dilution of 1:100
Select
F9 / Factor IX Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC
Unconjugated
50 µg/$294; 100 µg/$360
Select
F9 / Factor IX Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA
Biotin Conjugated
50 µg/$294; 100 µg/$360
Select
F9 / Factor IX Rat anti-Mouse Monoclonal (9041) Antibody
Mouse
ELISA, WB
Unconjugated
100 µg/$598
Select
F9 / Factor IX Rabbit anti-Human Monoclonal (Preservative Free) (044) Antibody
Human
ELISA
Unconjugated, Preservative Free
20 µl/$286; 100 µl/$435
F9 / Factor IX ELISA Kit
Select
Sandwich CLIA
12 x 8-Well Microstrips
Mouse
31.25 - 2000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$728
F9 / Factor IX ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
0.5 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$805
Viewing 1-25 of 159 product results



If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).