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F3 / CD142 / Tissue factor

coagulation factor III (thromboplastin, tissue factor)

F3 / CD142 / Tissue factor is coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease cascades, which circulate as nonfunctional precursors, this factor is a potent initiator that is fully functional when expressed on cell surfaces. There are 3 distinct domains of this factor: extracellular, transmembrane, and cytoplasmic. This protein is the only one in the coagulation pathway for which a congenital deficiency has not been described. Alternate splicing results in multiple transcript variants.

Gene Name: coagulation factor III (thromboplastin, tissue factor)
Synonyms: F3, CD142, CD142 antigen, TFA, Tissue factor, Thromboplastin, Coagulation factor III
Target Sequences: NM_001993 NP_001984.1 P13726

Publications (6)

1
Chloroquine reduces hypercoagulability in pancreatic cancer through inhibition of neutrophil extracellular traps. Boone BA, Murthy P, Miller-Ocuin J, Doerfler WR, Ellis JT, Liang X, Ross MA, Wallace CT, Sperry JL, Lotze MT, Neal MD, Zeh HJ 3rd. BMC cancer. 2018 June;18:678. [Full Text Article] [PubMed:29929491] [PMC:PMC6013899]
2
Procoagulant extracellular vesicles in amniotic fluid. Lena Hell, Lukas Wisgrill, Cihan Ay, Andreas Spittler, Michael Schwameis, Bernd Jilma, Ingrid Pabinger, Peter Altevogt, Johannes Thaler. Translational research : the journal of laboratory and clinical medicine. 2017 June;184:12-20.e1. [Full Text Article] [PubMed:28236427] [PMC:PMC6544525]
3
Using annexin V-coated magnetic beads to capture active tissue factor-bearing microparticles from body fluids. Frank Gieseler, Hans Gamperl, Frederike Theophil, Inga Stenzel, Tabea Quecke, Hendrik Ungefroren, Hendrik Lehnert. Cell biology international. 2014 Feburary;38:277-81. [Full Text Article] [PubMed:24431236]
4
Mammalian adipogenesis regulator (Areg) cells use retinoic acid signalling to be non- and anti-adipogenic in age-dependent manner. Magda Zachara , Pernille Y Rainer , Horia Hashimi , Julie M Russeil, Daniel Alpern, Radiana Ferrero, Maria Litovchenko, Bart Deplancke. The EMBO journal. 2022 September;41:e108206. [Full Text Article] [PubMed:35996853] [PMC:PMC9475530]
5
Early treatment with Fibrinogen ?-chain peptide-coated, ADP-encapsulated Liposomes (H12-(ADP)-liposomes) ameliorates post-partum hemorrhage with coagulopathy caused by amniotic fluid embolism in rabbits. Koki Kaneko, Kohsuke Hagisawa, Manabu Kinoshita, Yuka Ohtsuka, Ruka Sasa, Morihiro Hotta, Daizoh Saitoh, Kimiya Sato, Shinji Takeoka, Katsuo Terui. AJOG global reports. 2023 November;3:100280. [Full Text Article] [PubMed:38046530] [PMC:PMC10690637]
6
Acute pancreatitis induces a transient hypercoagulable state in murine models. Pavan Rao, Britney Niemann, Brett Szeligo, Abby D Ivey, Pranav Murthy, Carl R Schmidt, Brian A Boone. Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]. 2023 April;23:306-313. [Full Text Article] [PubMed:36898897] [PMC:PMC10053619]
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Products
ELISA Kits (33)
Cell-Based (1)
Cell-Based Phosphorylation (1)
Competitive EIA (3)
Custom (2)
Development Kit (1)
Sandwich (22)
Sandwich CLIA (3)
F3 / CD142 / Tissue factor (33)
Human (12)
Mouse (8)
Rat (7)
Horse (1)
Pig (1)
Rabbit (3)
Product Group
DevKit DuoPlus (1)
12 x 8-Well Microstrips (2)
96-Well Microplate (10)
96-Well Strip Plate (20)
Antibody Pair and Standard (1)
No (31)
Yes (2)
Adherent Cell Cultures (2)
Cell Culture Supernatants (7)
Cell Lysates (7)
Plasma (29)
Serum (23)
Tissue Homogenates (6)
Urine (2)
F3 / CD142 / Tissue factor ELISA Kit
Select
Sandwich
96-Well Microplate
Human
6.14 - 1500 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$635
F3 / CD142 / Tissue factor ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
F3 / CD142 / Tissue factor ELISA Kit
Select
Sandwich
96-Well Microplate
Mouse
6.25 - 400 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$528
F3 / CD142 / Tissue factor ELISA Kit
Select
Sandwich
96-Well Microplate
Rabbit
15.625 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$565
F3 / CD142 / Tissue factor ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
15.63 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma
1 Plate/$782
F3 / CD142 / Tissue factor ELISA Kit
Select
Sandwich
96-Well Microplate
Mouse
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum
1 Plate/$699
F3 / CD142 / Tissue factor ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma
1 Plate/$715
F3 / CD142 / Tissue factor ELISA Kit
Select
Sandwich CLIA
96-Well Strip Plate
Mouse
2.74 - 2000 pg/ml
Chemiluminescent
Plasma
1 Plate/$871
F3 / CD142 / Tissue factor ELISA Kit
Select
Competitive EIA
96-Well Strip Plate
Mouse
0.5 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$805
F3 / CD142 / Tissue factor ELISA Kit
Select
Sandwich
12 x 8-Well Microstrips
Human
8 - 500 pg/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Plasma, Serum
1 Plate/$534
F3 / CD142 / Tissue factor ELISA Kit
Select
Cell-Based Phosphorylation
96-Well Microplate
Human
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$668
F3 / CD142 / Tissue factor ELISA Kit
Select
Sandwich
96-Well Microplate
Human
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Urine
1 Plate/$699
F3 / CD142 / Tissue factor ELISA Kit
Select
Cell-Based
96-Well Microplate
Human
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$534
F3 / CD142 / Tissue factor ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rabbit
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$715
F3 / CD142 / Tissue factor ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
15.63 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma
1 Plate/$598
F3 / CD142 / Tissue factor ELISA Kit
Select
Sandwich
96-Well Strip Plate
Pig
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma
1 Plate/$779
F3 / CD142 / Tissue factor ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$585
F3 / CD142 / Tissue factor ELISA Kit
Select
Custom
96-Well Strip Plate
Rat
Colorimetric - 450nm (TMB)
1 Plate/$585
F3 / CD142 / Tissue factor ELISA Kit
Select
Custom
96-Well Strip Plate
Colorimetric - 450nm (TMB)
1 Plate/$669
F3 / CD142 / Tissue factor ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
7.813 - 500 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
F3 / CD142 / Tissue factor ELISA Kit
Select
Sandwich CLIA
12 x 8-Well Microstrips
Rat
12.5 - 800 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$656
F3 / CD142 / Tissue factor ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum
1 Plate/$624
F3 / CD142 / Tissue factor ELISA Kit
Select
Development Kit
Antibody Pair and Standard
Rabbit
12.5 - 800 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Tissue Homogenates
500 Wells/$1,254; 1000 Wells/$1,867
F3 / CD142 / Tissue factor ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
6.25 - 400 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
F3 / CD142 / Tissue factor ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).