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F2 / Prothrombin / Thrombin

coagulation factor II (thrombin)

Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Finally, peptides derived from the C-terminus of this protein have antimicrobial activity against E. coli and P. aeruginosa. Mutations in F2 leads to various forms of thrombosis and dysprothrombinemia.

Gene Name: coagulation factor II (thrombin)
Family/Subfamily: Protease , Serine S1
Synonyms: F2, Prothrombin B-chain, Coagulation factor II, FACTOR II, Prothrombin, PT, RPRGL2, Serine protease, THPH1, Thrombin
Target Sequences: NM_000506 NP_000497.1 P00734

Publications (3)

1
Targeting the thrombin receptor modulates inflammation and astrogliosis to improve recovery after spinal cord injury. Radulovic M, Yoon H, Wu J, Mustafa K, Scarisbrick IA. Neurobiology of disease. 2016 93:226-42. (WB; Human) [Full Text Article] [PubMed:27145117] Related Antibodies: LS-C118750.
2
Production and control of coagulation proteins for factor X activation in human endothelial cells and fibroblasts. Clay T Cohen, Nancy A Turner, Joel L Moake. Scientific reports. 2020 Feb;10:2005. [Full Text Article] [PubMed:32029851] [PMC:PMC7005260]
3
Maternal plasma proteomics in a rat model of pregnancy complications reveals immune and pro-coagulant gene pathway activation. Tino W Sanchez, Bo Li, Christine Molinaro, Carlos A Casiano, Denise L Bellinger, Eugenia Mata-Greenwood. American journal of reproductive immunology (New York, N.Y. : 1989). 2020 February;83:e13205. [Full Text Article] [PubMed:31677200] [PMC:PMC8553409]

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F2 / Prothrombin / Thrombin ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.78 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$585
F2 / Prothrombin / Thrombin ELISA Kit
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Sandwich
96-Well Strip Plate
Human
1.563 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
F2 / Prothrombin / Thrombin ELISA Kit
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Sandwich
96-Well Microplate
Human
0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
F2 / Prothrombin / Thrombin ELISA Kit
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Sandwich
96-Well Strip Plate
Bovine
7.8 - 500 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$669
F2 / Prothrombin / Thrombin ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
1.56 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
F2 / Prothrombin / Thrombin ELISA Kit
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Cell-Based
96-Well Microplate
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$534
F2 / Prothrombin / Thrombin ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
1 - 500 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Media, Plasma, Serum, Tissue Extracts
1 Plate/$754
F2 / Prothrombin / Thrombin ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
1 - 500 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Media, Plasma, Serum, Tissue Extracts
1 Plate/$604
F2 / Prothrombin / Thrombin ELISA Kit
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Sandwich
96-Well Microplate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
F2 / Prothrombin / Thrombin ELISA Kit
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Sandwich
96-Well Strip Plate
Human
4.69 - 300 ng/ml
Colorimetric - 450nm (TMB)
Serum
1 Plate/$764
F2 / Prothrombin / Thrombin ELISA Kit
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Competitive EIA
96-Well Strip Plate
Rat
2.5 - 50 mg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$805
F2 / Prothrombin / Thrombin ELISA Kit
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Sandwich
96-Well Microplate
Human
9.375 - 600 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
F2 / Prothrombin / Thrombin ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.25 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma
1 Plate/$590
F2 / Prothrombin / Thrombin ELISA Kit
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Custom
96-Well Strip Plate
Pig
Colorimetric - 450nm (TMB)
1 Plate/$669
F2 / Prothrombin / Thrombin ELISA Kit
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Custom
96-Well Strip Plate
Mouse
Colorimetric - 450nm (TMB)
1 Plate/$669
F2 / Prothrombin / Thrombin ELISA Kit
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Sandwich
96-Well Strip Plate
Monkey
0.781 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
F2 / Prothrombin / Thrombin ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
F2 / Prothrombin / Thrombin ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
F2 / Prothrombin / Thrombin ELISA Kit
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Sandwich
96-Well Strip Plate
Rabbit
1.563 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
F2 / Prothrombin / Thrombin ELISA Kit
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Sandwich CLIA
12 x 8-Well Microstrips
Rat
31.25 - 2000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$656
F2 / Prothrombin / Thrombin ELISA Kit
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Sandwich CLIA
12 x 8-Well Microstrips
Mouse
31.25 - 2000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$656
F2 / Prothrombin / Thrombin ELISA Kit
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Sandwich CLIA
12 x 8-Well Microstrips
Human
31.25 - 2000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$656
F2 / Prothrombin / Thrombin ELISA Kit
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Sandwich
96-Well Strip Plate
Chicken
1.563 - 100 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
F2 / Prothrombin / Thrombin ELISA Kit
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Sandwich
96-Well Strip Plate
Guinea pig
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
F2 / Prothrombin / Thrombin ELISA Kit
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Sandwich
96-Well Strip Plate
Monkey
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).