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The cytoplasmic peripheral membrane protein encoded by this gene functions as a protein-tyrosine kinase substrate in microvilli. As a member of the ERM protein family, this protein serves as an intermediate between the plasma membrane and the actin cytoskeleton. This protein plays a key role in cell surface structure adhesion, migration and organization, and it has been implicated in various human cancers. A pseudogene located on chromosome 3 has been identified for this gene. Alternatively spliced variants have also been described for this gene.
Gene Name: | ezrin |
Synonyms: | EZR, CVIL, Cytovillin, CVL, p81, VIL2, Villin 2 (ezrin), Villin-2, Cytovillin 2, Ezrin |
Target Sequences: | NM_003379 NP_003370.2 P15311 |
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