EZH2

enhancer of zeste homolog 2 (Drosophila)

Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Compared to EZH2-containing complexes, it is more abundant in embryonic stem cells and plays a major role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1, CDKN2A and retinoic acid target genes. EZH2 can also methylate non-histone proteins such as the transcription factor GATA4 and the nuclear receptor RORA. Regulates the circadian clock via histone methylation at the promoter of the circadian genes. Essential for the CRY1/2-mediated repression of the transcriptional activation of PER1/2 by the CLOCK-ARNTL/BMAL1 heterodimer; involved in the di and trimethylation of 'Lys-27' of histone H3 on PER1/2 promoters which is necessary for the CRY1/2 proteins to inhibit transcription.

☰ Filters

Products

Antibodies (78)

Proteins (12)

ELISA Kits (5)

Type

Over-Expression Lysate (6)

Primary (78)

Recombinant (6)

Sandwich (4)

Sandwich CLIA (1)

Target

EZH2 (95)

Reactivity

Human (82)

Mouse (24)

Rat (9)

Bat (3)

Bovine (3)

Chicken (3)

Chimpanzee (3)

Dog (3)

Gibbon (3)

Guinea pig (3)

Hamster (3)

Horse (3)

Monkey (3)

Pig (3)

Rabbit (8)

Xenopus (3)

Zebrafish (3)

more less

Application

IHC (34)

IHC-P (5)

WB (74)

Flo (7)

ELISA (25)

ICC (13)

IF (19)

IP (5)

Peptide-ELISA (3)

Host

rabbit (56)

mouse (22)

Product Group

IHCPlus (2)

Isotype

IgG (32)

IgG1 (5)

IgG1,k (13)

IgG2b (2)

IgG2b,k (1)

Clonality

monoclonal mc (21)

polyclonal pc (57)

Clone

144CT2.1.1.5 (6)

2C3 (1)

6G4F4 (1)

OTI10B10 (2)

OTI2B10 (2)

UMAB264 (2)

Format

96-Well Strip Plate (5)

APC (2)

APC Conjugated (7)

Azide-free (3)

Biotin Conjugated (8)

Carrier-free (3)

Cy3 Conjugated (2)

Cy7 Conjugated (2)

FITC Conjugated (8)

HRP Conjugated (8)

PE Conjugated (7)

Unconjugated (36)

more less

Epitope

N-Terminus (11)

aa51-285 (8)

aa559-747 (8)

aa182-431 (6)

Internal (1)

aa1-250 (1)

aa1-286 (1)

aa175-225 (1)

aa260-295 (1)

aa696-746 (1)

pThr367 (1)

more less

Publications

No (95)

Sample Type

Cell Lysates (1)

Plasma (3)

Serum (3)

Tissue Homogenates (3)

Tag

6His, N-terminus (1)

GST (1)

GST, N-terminus (1)

His, N-Terminal (1)

His-T7 (1)

Myc-DDK (Flag) (7)

Species

Human (9)

Source

293T Cells (3)

E. coli (3)

HEK 293 Cells (4)

Wheat Germ Extract (2)

Purification

Purified (1)

Select

IHC-plus™ EZH2 Antibody LS-B7096

(4.0) Rating

Antibody:

EZH2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, ICC, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

0.05 mg/$460

Select

IHC-plus™ EZH2 Antibody (Internal) LS-B2528

(4.0) Rating

Antibody:

EZH2 Rabbit anti-Human Polyclonal (Internal) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$485

Select

EZH2 Antibody LS-C167873

Antibody:

EZH2 Mouse anti-Human Monoclonal Antibody

Reactivity:

Human

Applications:

IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

400 µl/$393

Select

EZH2 Antibody LS-C668256

Antibody:

EZH2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

ICC, IF, WB

Format:

Unconjugated

Price:

30 µl/$266; 50 µl/$286; 100 µl/$321; 200 µl/$386

Select

EZH2 Antibody (phospho-Thr367) LS-C829902

Antibody:

EZH2 Rabbit anti-Human Polyclonal (pThr367) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$421

Select

EZH2 Antibody (aa1-286) LS-C125574

Antibody:

EZH2 Mouse anti-Human Monoclonal (aa1-286) Antibody

Reactivity:

Mouse, Human

Applications:

WB

Format:

Unconjugated

Price:

100 µg/$973

Select

Human EZH2 Protein (Recombinant His-T7) (aa559-747) - LS-G26049

Source:

E. coli

Tag:

His-T7

Molecular Weight:

25.1 kDa

Price:

10 µg/$271; 50 µg/$382; 100 µg/$610; 200 µg/$762; 1 mg/$1,817; 500 µg/$1,378; 5 mg/$2,775; 2 mg/$1,998

Select

Human EZH2 (Sandwich ELISA) ELISA Kit - LS-F7278

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$730

Select

EZH2 Antibody LS-C746880

Antibody:

EZH2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, WB

Format:

Unconjugated

Price:

20 µl/$275; 100 µl/$389

Select

EZH2 Antibody (N-Terminus) LS-C151203

Antibody:

EZH2 Rabbit anti-Human Polyclonal (N-Terminus) Antibody

Reactivity:

Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

100 µl/$424

Select

EZH2 Antibody LS-C321238

Antibody:

EZH2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IF, IHC, WB

Format:

Unconjugated

Price:

200 µl/$734

Select

EZH2 Antibody (Biotin) LS-C214081

Antibody:

EZH2 Rabbit anti-Human Polyclonal (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, ICC, IF, IHC, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

Select

EZH2 Antibody (FITC) LS-C214082

Antibody:

EZH2 Rabbit anti-Human Polyclonal (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, ICC, IF, IHC, WB

Format:

FITC Conjugated

Price:

200 µl/$952

Select

EZH2 Antibody (APC) LS-C214080

Antibody:

EZH2 Rabbit anti-Human Polyclonal (APC) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, ICC, IF, IHC, WB

Format:

APC Conjugated

Price:

200 µl/$952

Select

EZH2 Antibody (Azide-free, HRP) LS-C214083

Antibody:

EZH2 Rabbit anti-Human Polyclonal (Azide-free) (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, ICC, IF, IHC, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

Select

EZH2 Antibody (PE) LS-C214084

Antibody:

EZH2 Rabbit anti-Human Polyclonal (PE) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, ICC, IF, IHC, WB

Format:

PE Conjugated

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• APC
• HRP, Azide-free
• PE

• Unconjugated
• Biotin
• FITC
• More...
  • APC
  • HRP, Azide-free
  • PE

Select

EZH2 Antibody (clone 144CT2.1.1.5) LS-C319151

Antibody:

EZH2 Mouse anti-Human Monoclonal (144CT2.1.1.5) Antibody

Reactivity:

Human

Applications:

ICC, IF, IHC, WB

Format:

Unconjugated

Price:

200 µl/$734

Select

EZH2 Antibody (clone 144CT2.1.1.5, Biotin) LS-C212439

Antibody:

EZH2 Mouse anti-Human Monoclonal (Biotin) (144CT2.1.1.5) Antibody

Reactivity:

Human

Applications:

ELISA, ICC, IF, IHC, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

Select

EZH2 Antibody (clone 144CT2.1.1.5, FITC) LS-C212440

Antibody:

EZH2 Mouse anti-Human Monoclonal (FITC) (144CT2.1.1.5) Antibody

Reactivity:

Human

Applications:

ELISA, ICC, IF, IHC, WB

Format:

FITC Conjugated

Price:

200 µl/$952

Select

EZH2 Antibody (clone 144CT2.1.1.5, PE) LS-C212442

Antibody:

EZH2 Mouse anti-Human Monoclonal (PE) (144CT2.1.1.5) Antibody

Reactivity:

Human

Applications:

ELISA, ICC, IF, IHC, WB

Format:

PE Conjugated

Price:

200 µl/$952

Select

EZH2 Antibody (clone 144CT2.1.1.5, Azide-free, HRP) LS-C212441

Antibody:

EZH2 Mouse anti-Human Monoclonal (Azide-free) (HRP) (144CT2.1.1.5) Antibody

Reactivity:

Human

Applications:

ELISA, ICC, IF, IHC, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

Select

EZH2 Antibody (clone 144CT2.1.1.5, APC) LS-C221204

Antibody:

EZH2 Mouse anti-Human Monoclonal (APC) (144CT2.1.1.5) Antibody

Reactivity:

Human

Applications:

ELISA, ICC, IF, IHC, WB

Format:

APC Conjugated

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• PE
• HRP, Azide-free
• APC

• Unconjugated
• Biotin
• FITC
• More...
  • PE
  • HRP, Azide-free
  • APC

Select

EZH2 Antibody LS-C754700

Antibody:

EZH2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, IP, WB

Format:

Unconjugated

Price:

100 µg/$341

Select

Human EZH2 (Sandwich ELISA) ELISA Kit - LS-F31919

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

31.25 - 2000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

Select

Mouse EZH2 (Sandwich ELISA) ELISA Kit - LS-F49779

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$669

Viewing 1-25 of 95 product results

(0) Selected Add Selected To Cart Compare Selected Email Selected Clear Selected Top Of Search

If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.