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ETV6 / TEL is an ETS family transcription factor. The product of this gene contains two functional domains: a N-terminal pointed (PNT) domain that is involved in protein-protein interactions with itself and other proteins, and a C-terminal DNA-binding domain. Gene knockout studies in mice suggest that it is required for hematopoiesis and maintenance of the developing vascular network. This gene is known to be involved in a large number of chromosomal rearrangements associated with leukemia and congenital fibrosarcoma.
Gene Name: | ets variant 6 |
Synonyms: | ETV6, ETS translocation variant 6, Ets variant gene 6, ETS-related protein Tel1, TEL/ABL, TEL1 oncogene, Transcription factor ETV6, Ets variant 6, TEL, TEL1 |
Target Sequences: | NM_001987 NP_001978.1 P41212 |
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