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ERVWE1 / HERV / Syncytin

Endogenous Retrovirus group W, member 1

Many different human endogenous retrovirus (HERV) families are expressed in normal placental tissue at high levels, suggesting that HERVs are functionally important in reproduction. This gene is part of an HERV provirus on chromosome 7 that has inactivating mutations in the gag and pol genes. This gene is the envelope glycoprotein gene which appears to have been selectively preserved. The gene's protein product is expressed in the placental syncytiotrophoblast and is involved in fusion of the cytotrophoblast cells to form the syncytial layer of the placenta. The protein has the characteristics of a typical retroviral envelope protein, including a furin cleavage site that separates the surface (SU) and transmembrane (TM) proteins which form a heterodimer. Alternatively spliced transcript variants encoding the same protein have been found for this gene.

Gene Name: Endogenous Retrovirus group W, member 1
Synonyms: ERVW-1, Env-W, Envelope polyprotein gPr73, ERVWE1, HERV-W-ENV, Envelope glycoprotein, Enverin, ENVW, HERV-7q Envelope protein, HERV-W Env glycoprotein, HERV-W envelope protein, HERVW, Syncytin A, Syncytin-1, env, Envelope protein, HERV-7q, HERV-W, HERV7Q, HERVWENV, Syncytin
Target Sequences: NP_055405.3 Q9UQF0

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Proteins (3)
Recombinant (3)
ERVWE1 / HERV / Syncytin (3)
Product Group
Retroviridae (3)
No (3)
6His, N-terminus (1)
6His-SUMO, N-terminus (1)
GST (1)
Human (3)
E. coli (1)
Yeast (1)
Purified (2)
ERVWE1 / HERV / Syncytin Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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Yeast
6His, N-terminus
49.0 kDa
100 µg/$570; 20 µg/$395; 1 mg/$1,973
ERVWE1 / HERV / Syncytin Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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E. coli
6His-SUMO, N-terminus
1 mg/$1,679; 100 µg/$500; 20 µg/$364
ERVWE1 / HERV / Syncytin Protein
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GST
36.74kDa
10 µg/$479; 25 µg/$670
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).