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ERVFRD-1 / HERV-FRD
Endogenous Retrovirus group FRD, member 1
Many different human endogenous retrovirus (HERV) families are expressed in normal placental tissue at high levels, suggesting that HERVs are functionally important in reproduction. This gene is part of a human endogenous retrovirus provirus on chromosome 6 that has inactivating mutations in the gag and pol genes. This gene is the envelope glycoprotein gene which appears to have been selectively preserved. The gene's protein product plays a major role in placental development and trophoblast fusion. The protein has the characteristics of a typical retroviral envelope protein, including a cleavage site that separates the surface (SU) and transmembrane (TM) proteins which form a heterodimer.
| Gene Name: | Endogenous Retrovirus group FRD, member 1 |
| Synonyms: | ERVFRD-1, GLLL6191, Envelope polyprotein, EnvFRD, ERVFRDE1, HERV-FRD, UNQ6191, Syncytin-2, HERV-W/FRD, Syncytin 2 |
| Target Sequences: | R98276 NP_997465.1 P60508 |
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